The goldilocks oxygen principle: not too little and not too much

Nature has evolved creative ways to maintain oxygen homeostasis, but what happens when these adaptations are insufficient? Here we discuss biochemical failure points across the oxygen

spectrum from ‘too little’ to ‘too much’ oxygen and their potential contributions to cardiovascular disease. Access through your institution Buy or subscribe This is a preview of

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ast, T. & Mootha, V. K. _Nat.

Metab._ 1, 858–860 (2019). Article  CAS  Google Scholar  * Park, T. J. et al. _Science_ 356, 307–311 (2017). Article  CAS  Google Scholar  * Clark, J. M. & Lambertsen, C. J. _Pharmacol.

Rev._ 23, 37–133 (1971). CAS  Google Scholar  * Frank, A. et al. _Semin. Cardiothorac. Vasc. Anesth._ 16, 123–132 (2012). * Farber, H. W. et al. _J. Heart Lung Transplant_ 37, 948–955

(2018). Article  Google Scholar  * Stub, D. et al. & AVOID Investigators. _Circulation_ 131, 2143–2150 (2015). Article  CAS  Google Scholar  * Stanley, W. C., Recchia, F. A. &

Lopaschuk, G. D. _Physiol. Rev._ 85, 1093–1129 (2005). Article  CAS  Google Scholar  * Otsuka, S., Matsumoto, K., Nakajima, M., Tanaka, T. & Ogura, S. _PLoS ONE_ 10, e0146026 (2015).

Article  Google Scholar  * Devlin, C. M. et al. _J. Biol. Chem._ 286, 38069–38078 (2011). Article  CAS  Google Scholar  * Koritzinsky, M. et al. _J. Cell Biol._ 203, 615–627 (2013). Article

  CAS  Google Scholar  * Thienpont, B. et al. _Nature_ 537, 63–68 (2016). Article  CAS  Google Scholar  * Bienfait, H. F., Jacobs, J. M. C. & Slater, E. C. _Biochim. Biophys. Acta_ 376,

446–457 (1975). Article  CAS  Google Scholar  * Boehme, D. E., Vincent, K. & Brown, O. R. _Nature_ 262, 418–420 (1976). Article  CAS  Google Scholar  * Jain, I. H. et al. _Science_ 352,

54–61 (2016). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS I.H.J. was supported by US National Institutes of Health (NIH) DP5 DP5OD026398. W.R.F. was supported by NIH

R01AG065428. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Gladstone Institutes, San Francisco, CA, USA Will R. Flanigan & Isha H. Jain * UCSF-UC Berkeley Joint PhD Program in

Bioengineering, Berkeley, CA, USA Will R. Flanigan * Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA Isha H. Jain * Cardiovascular

Research Institute, University of California, San Francisco, San Francisco, CA, USA Isha H. Jain Authors * Will R. Flanigan View author publications You can also search for this author

inPubMed Google Scholar * Isha H. Jain View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Isha H. Jain. ETHICS

DECLARATIONS COMPETING INTERESTS I.H.J. is a consultant for Maze Therapeutics. W.R.F. declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Flanigan, W.R., Jain, I.H. The Goldilocks Oxygen Principle: not too little and not too much. _Nat Cardiovasc Res_ 1, 1101–1103 (2022).

https://doi.org/10.1038/s44161-022-00178-7 Download citation * Published: 12 December 2022 * Issue Date: December 2022 * DOI: https://doi.org/10.1038/s44161-022-00178-7 SHARE THIS ARTICLE

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