Starvation induces metabolic hepatocyte reprogramming

The liver performs gluconeogenesis, the de novo production of glucose during extended fasting and starvation. A study by Okada et al. now highlights spatiotemporal metabolic reprogramming in

hepatocytes during metabolic transitions between feeding states. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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subscriptions * Read our FAQs * Contact customer support REFERENCES * Petersen, M. C., Vatner, D. F. & Shulman, G. I. _Nat. Rev. Endocrinol._ 13, 572–587 (2017). Article  CAS  PubMed 

PubMed Central  Google Scholar  * Ben-Moshe, S. & Itzkovitz, S. _Nat. Rev. Gastroenterol. Hepatol._ 16, 395–410 (2019). Article  PubMed  Google Scholar  * Droin, C. et al. _Nat. Metab._

3, 43–58 (2021). Article  CAS  PubMed  PubMed Central  Google Scholar  * Martini, T., Naef, F. & Tchorz, J. S. _Annu. Rev. Pathol._ 18, 439–466 (2023). Article  CAS  PubMed  Google

Scholar  * Okada, J. et al. _Nat. Metab._ https://doi.org/10.1038/s42255-025-01269-y (2025). * Gallage, S. et al. _Cell Metab._ 36, 1371–1393.e7 (2024). Article  CAS  PubMed  Google Scholar

  * Russell, J. O. & Monga, S. P. _Annu. Rev. Pathol._ 13, 351–378 (2018). Article  CAS  PubMed  Google Scholar  * Sun, T. et al. _Cell Stem Cell_ 28, 1822–1837.e1810 (2021). Article 

CAS  PubMed  Google Scholar  * Uno, K. et al. _PLoS Biol._ 23, e3002955 (2025). Article  CAS  PubMed  PubMed Central  Google Scholar  * Gougelet, A. et al. _Hepatology_ 59, 2344–2357 (2014).

Article  CAS  PubMed  Google Scholar  * Saponara, E. et al. _Am. J. Pathol._ 193, 161–181 (2023). Article  CAS  PubMed  Google Scholar  * Stekovic, S. et al. _Cell Metab._ 30, 462–476.e6

(2019). Article  CAS  PubMed  Google Scholar  * Ben-Moshe, S. et al. _Nat. Metab._ 1, 899–911 (2019). Article  CAS  PubMed  PubMed Central  Google Scholar  * Halpern, K. B. et al. _Nature_

542, 352–356 (2017). Article  CAS  PubMed  PubMed Central  Google Scholar  * Gribben, C. et al. _Nature_ 630, 166–173 (2024). Article  CAS  PubMed  PubMed Central  Google Scholar  Download

references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland Coenraad F. Slabber & Jan S. Tchorz Authors * Coenraad F.

Slabber View author publications You can also search for this author inPubMed Google Scholar * Jan S. Tchorz View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to Jan S. Tchorz. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Slabber, C.F., Tchorz, J.S. Starvation induces metabolic hepatocyte reprogramming. _Nat Metab_ 7, 864–866 (2025).

https://doi.org/10.1038/s42255-025-01286-x Download citation * Published: 25 April 2025 * Issue Date: May 2025 * DOI: https://doi.org/10.1038/s42255-025-01286-x SHARE THIS ARTICLE Anyone you

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