The pig as an optimal animal model for cardiovascular research

ABSTRACT Cardiovascular disease is a worldwide health problem and a leading cause of morbidity and mortality. Preclinical cardiovascular research using animals is needed to explore potential

targets and therapeutic options. Compared with rodents, pigs have many advantages, with their anatomy, physiology, metabolism and immune system being more similar to humans. Here we present

an overview of the available pig models for cardiovascular diseases, discuss their advantages over other models and propose the concept of standardized models to improve translation to the

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PRACTICAL GUIDE TO SETTING UP PIG MODELS FOR CARDIOVASCULAR CATHETERIZATION, ELECTROPHYSIOLOGICAL ASSESSMENT AND HEART DISEASE RESEARCH Article 27 January 2022 THE CARDIAC MOLECULAR SETTING

OF METABOLIC SYNDROME IN PIGS REVEALS DISEASE SUSCEPTIBILITY AND SUGGESTS MECHANISMS THAT EXACERBATE COVID-19 OUTCOMES IN PATIENTS Article Open access 05 October 2021 HEMATOLOGIC AND

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Download references ACKNOWLEDGEMENTS This work was supported by the National Natural Science Fund for Distinguished Young Scholars of China (82125004; to J.S.) and the Frontier Biotechnology

Key Project of National Key R & D Program of the Ministry of Science and Technology of China (2023YFC3404300; to J.S.). AUTHOR INFORMATION Author notes * These authors contributed

equally: Hao Jia, Yuan Chang. AUTHORS AND AFFILIATIONS * Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre,

National Centre for Cardiovascular Disease, Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Hao Jia, Yuan

Chang & Jiangping Song * Sanya Institute of China Agricultural University, Sanya, China Jiangping Song Authors * Hao Jia View author publications You can also search for this author

inPubMed Google Scholar * Yuan Chang View author publications You can also search for this author inPubMed Google Scholar * Jiangping Song View author publications You can also search for

this author inPubMed Google Scholar CONTRIBUTIONS J.S. contributed to the article’s conceptualization. H.J. was instrumental in drafting and revising the manuscript. Y.C. was responsible for

drafting the manuscript and designing the figure. CORRESPONDING AUTHOR Correspondence to Jiangping Song. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.

PEER REVIEW PEER REVIEW INFORMATION _Lab Animal_ thanks Verónica Crisóstomo and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. ADDITIONAL

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