Author correction: three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

Correction to: _Scientific Reports_ https://doi.org/10.1038/srep42212, published online 07 February 2017 This Article contains typographical errors. In the Introduction section, “Although

the direct administration of biological factors to injury sites is frequently applied, such an approach often does not lead to robust tissue regeneration and reformation due to the rapid

biological clearance of these agents from our bodies1,2,3,4. Given this limitation, biodegradable scaffolds are increasingly employed as temporary frameworks for sustained delivery of

biomolecules and to support neo-tissue formation.” should read: “Although the direct administration of biological factors to injury sites is frequently applied, such an approach often does

not lead to robust tissue regeneration and reformation due to the degradation and rapid biological clearance of these agents from our bodies1,2,3. Given this limitation, biodegradable

scaffolds are increasingly employed as temporary frameworks for sustained delivery of biomolecules and to support neo-tissue formation4.” “On the other hand, miR-222 is enriched in axons and

participates in controlling local protein synthesis at distal axons36-38. Such controlled local protein synthesis plays crticial roles in allowing severed axons to undergo regeneration

within hours after injuries, independent of protein transport from the cell soma of neurons36,39. Unfortunately, the expression of miR-222 is often significantly altered after nerve

injuries40-46. _In vitro_, when miR-222 was deliberately over-expressed in injured adult neurons, enhanced regrowth was observed40,41,47,48.” should read: “On the other hand, miR-22241 is

one of the miRs that is enriched in axons and participates in controlling local protein synthesis at distal axons36-38,41. Such controlled local protein synthesis plays crticial roles in

allowing severed axons to undergo regeneration within hours after injuries, independent of protein transport from the cell soma of neurons36,39. Unfortunately, the expression of these

miRs40–46, and in particular, miR-22241 is often significantly altered after nerve injuries. _In vitro_, when miR-222 was deliberately over-expressed in injured adult neurons, enhanced

regrowth was observed41.” In the Materials and Methods section, under subheading ‘Aligned PCLEEP fibers’, “The PCLEEP copolymer (Mw = 59,102, Mn = 25,542) was synthesized by previously

reported methods43,50.” should read: “The PCLEEP copolymer (Mw = 59,102, Mn = 25,542) was synthesized by previously reported methods50.” In the Results and Discussion section, “Among the

scaffolds analyzed, hydrogels8,14,52,53,54,55,56,57,58 and self-assembled peptide nanofibers59,60 are most popular.” should read: “Among the scaffolds analyzed,

hydrogels7,8,14,52,55,56,57,58 and self-assembled peptide nanofibers9,10 are most popular.” “Similarly, the fibrin scaffold by Taylor _et al_. could only deliver NT-3 for 2 weeks

post-implantation due to the rapid scaffold degradation rate63.” should read: “Similarly, the fibrin scaffold by Taylor _et al_. could only deliver NT-3 for 2 weeks post-implantation due to

the rapid scaffold degradation rate55.” “Such controlled local protein synthesis at distal axons has allowed severed axons to undergo regeneration within hours after injuries35,45. This

local protein synthesis is finely controlled by microRNAs, such as miR-222. Indeed, miR-222 enhanced axonal regrowth in injured adult neurons _in vitro_40,41,47,48.” should read: “Such

controlled local protein synthesis at distal axons has allowed severed axons to undergo regeneration within hours after injuries36,39. This local protein synthesis is finely controlled by

microRNAs40,41,47,48, such as miR-22241. Indeed, miR-222 enhanced axonal regrowth in injured adult neurons _in vitro_41.” “To replenish this OL pool, oligodendrocyte precursor cells (OPCs)

proliferate and are recruited to the lesion site for differentiation and remyelination74,75.” should read: “To replenish this OL pool, oligodendrocyte precursor cells (OPCs) proliferate and

are recruited to the lesion site for differentiation and remyelination74.” In the References section, reference 50 was incorrectly given as: Xiao, C.-S., Wang, Y.-C., Du, J.-Z., Chen, X.-S.

& Wang, J. Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate. _Macromolecules_ 39, 6825–6831, doi: 10.1021/ma0615396 (2006).

The correct reference is listed below as reference 1. In addition, references 54, 59, 60 and 63 are duplicates of references 7, 9, 10 and 55 respectively. REFERENCE * Wang, Y.-C., Li, Y.,

Yang, X.-Z., Yuan, Y.-Y., Yan, L.-F. & Wang, J. Tunable Thermosensitivity of Biodegradable Polymer Micelles of Poly(ε-caprolactone) and Polyphosphoester Block Copolymers.

_Macromolecules_ 42(8), 3026–3032, https://doi.org/10.1021/ma900288t (2009). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION Author notes * Mingyong Gao Present address:

Department of spinal surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, PR China * Lan Huong Nguyen and Mingyong Gao contributed equally. AUTHORS AND AFFILIATIONS * School of

Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, 637459, Singapore Lan Huong Nguyen, Mingyong Gao, Junquan Lin & Sing Yian Chew * Department of Spine

Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China Mingyong Gao * School of Biomedical Sciences, The University of Hong Kong Li Ka Shing Faculty of Medicine, Pokfulam, Hong

Kong SAR, China Wutian Wu * Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China Wutian Wu *

State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China Wutian Wu * Guangdong-Hongkong-Macau

Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, PR China Wutian Wu * The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical

Center, University of Science & Technology of China, Hefei, Anhui, 230027, PR China Jun Wang * Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232,

Singapore Sing Yian Chew Authors * Lan Huong Nguyen View author publications You can also search for this author inPubMed Google Scholar * Mingyong Gao View author publications You can also

search for this author inPubMed Google Scholar * Junquan Lin View author publications You can also search for this author inPubMed Google Scholar * Wutian Wu View author publications You can

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license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nguyen, L.H., Gao, M., Lin, J. _et al._ Author Correction:

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment. _Sci Rep_ 8, 13057 (2018).

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