The hunt for rna polymerase ii elongation factors: a historical perspective

ABSTRACT The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious biochemical investigations of eukaryotic transcription and the identification of eukaryotic

transcription factors. Here we describe this adventure from our vantage point, with a focus on the hunt for factors that regulate elongation by RNA polymerase II. Access through your

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INSIGHTS INTO NUCLEAR TRANSCRIPTION BY EUKARYOTIC DNA-DEPENDENT RNA POLYMERASES Article 03 May 2022 TRANSCRIPTION FACTORS MODULATE RNA POLYMERASE CONFORMATIONAL EQUILIBRIUM Article Open

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PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We thank J. Weems for help with figures and all of the many colleagues who have contributed to our laboratory’s research on Pol

II elongation over the years. Because of length limitations, we have not provided exhaustive references and in some cases have cited reviews rather than primary papers. We apologize to those

whose contributions to the primary literature were not cited. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Stowers Institute for Medical Research, Kansas City, MO, USA Ronald C. Conaway 

& Joan W. Conaway * Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA Ronald C. Conaway & Joan W. Conaway Authors * Ronald

C. Conaway View author publications You can also search for this author inPubMed Google Scholar * Joan W. Conaway View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHOR Correspondence to Joan W. Conaway. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ADDITIONAL INFORMATION PEER REVIEW

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THIS ARTICLE Conaway, R.C., Conaway, J.W. The hunt for RNA polymerase II elongation factors: a historical perspective. _Nat Struct Mol Biol_ 26, 771–776 (2019).

https://doi.org/10.1038/s41594-019-0283-1 Download citation * Received: 10 June 2019 * Accepted: 18 July 2019 * Published: 22 August 2019 * Issue Date: September 2019 * DOI:

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