TH17 cell flavors | Nature Immunology

Access through your institution Buy or subscribe _Immunity_ https://doi.org/10.1016/j.immuni.2019.05.004 (2019) The TH17 subset of helper T cells is pathogenic in a variety of inflammatory

disorders but also has tissue-resident homeostatic roles in the intestine. In _Immunity_, Omenetti et al. compare the characteristics of TH17 cells induced by commensal microbiota, notably

segmented filamentous bacteria (SFB), and those elicited by a pathogen (_Citrobacter rodentium_). Secretion of the cytokine IL-17A is higher in SFB-induced TH17 cells, the cytokine IFN-γ is

more abundant in _C. rodentium_–elicited TH17 cells, and both groups of cells produce IL-22. SFB-induced TH17 cells do not expand in response to infection with _C. rodentium_. RNA-sequencing

analysis indicates enrichment for transcripts encoding molecules involved in anti-inflammatory pathways and oxidative phosphorylation in SFB-induced TH17 cells and enrichment for markers of

glycolysis, biosynthesis and pro-inflammatory pathways in _C. rodentium_–elicited TH17 cells. These results indicate that two functionally distinct populations of TH17 cells can reside in

the gut simultaneously during pathogen-induced inflammation. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access

Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print

issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to

local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Nature Immunology https://www.nature.com/natimmunol Ioana Visan Authors * Ioana Visan View author publications You can also search for this author inPubMed Google

Scholar CORRESPONDING AUTHOR Correspondence to Ioana Visan. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Visan, I. TH17 cell flavors. _Nat Immunol_

20, 945 (2019). https://doi.org/10.1038/s41590-019-0459-1 Download citation * Published: 19 July 2019 * Issue Date: August 2019 * DOI: https://doi.org/10.1038/s41590-019-0459-1 SHARE THIS

ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard

Provided by the Springer Nature SharedIt content-sharing initiative