No job too small for a giant enzyme

Modular polyketide synthases are multidomain megasynthases catalyzing polyketide chain elongation, modification and release. New work reveals a full ~360-kDa modular polyketide synthases

with just one active domain, ketosynthase, catalyzing an amidation that releases the completed product (a reaction type typically catalyzed by dedicated thioesterases). Access through your

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Fischbach, M. A. & Walsh, C. T.

_Chem. Rev._ 106, 3468–3496 (2006). Article  CAS  PubMed  Google Scholar  * Kwon, H.-J. et al. _Science_ 297, 1327–1330 (2002). Article  CAS  PubMed  Google Scholar  * Bretschneider, T. et

al. _Nat. Chem. Biol._ 8, 154–161 (2012). Article  CAS  Google Scholar  * Yun, C.-S., Motoyama, T. & Osada, H. _Nat. Commun._ 6, 8758 (2015). Article  CAS  PubMed  Google Scholar  *

Bretschneider, T. et al. _Nature_ 502, 124–128 (2013). Article  CAS  PubMed  Google Scholar  * Masschelein, J. et al. _Nat. Chem._ 11, 906–912 (2019). Article  CAS  PubMed  PubMed Central 

Google Scholar  * Lv, M., Zhao, J., Deng, Z. & Yu, Y. _Chem. Biol._ 22, 1313–1324 (2015). Article  CAS  PubMed  Google Scholar  * Wang, J. et al. _Nat. Commun._ 14, 1319 (2023). Article

  CAS  PubMed  PubMed Central  Google Scholar  * Robbins, T., Kapilivsky, J., Cane, D. E. & Khosla, C. _Biochemistry_ 55, 4476–4484 (2016). Article  CAS  PubMed  Google Scholar  Download

references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA Zuodong Sun & 

Yi Tang * Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA Yi Tang Authors * Zuodong Sun View author publications You can also search for

this author inPubMed Google Scholar * Yi Tang View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Yi Tang. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sun, Z., Tang, Y. No job too

small for a giant enzyme. _Nat Chem Biol_ 19, 934–936 (2023). https://doi.org/10.1038/s41589-023-01386-3 Download citation * Published: 20 July 2023 * Issue Date: August 2023 * DOI:

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