Neisseria gonorrhoeae resistance driven by antibiotic use

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Neisseria gonorrhoeae resistance driven by antibiotic use"


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A new ecological analysis has shown that antimicrobial consumption is positively associated with decreased antimicrobial susceptibility in _Neisseria gonorrhoeae_ across European countries.


Efforts at the policy, provider and community level need to be strengthened to address and help mitigate the continued emergence of antimicrobial resistance in _N. gonorrhoeae_. Access


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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Olesen, S. W. & Grad,


Y. H. Deciphering the impact of bystander selection for antibiotic resistance in _Neisseria gonorrhoeae_. _J. Infect. Dis_. https://doi.org/10.1093/infdis/jiz156 (2019). * Kenyon, C. et al.


Population-level antimicrobial consumption is associated with decreased antimicrobial susceptibility in _Neisseria gonorrhoeae_ in 24 European countries: an ecological analysis. _J. Infect.


Dis_. https://doi.org/10.1093/infdis/jiz153 (2019). * Klausner, J. D. et al. Correlates of gonococcal infection and of antimicrobial-resistant _Neisseria gonorrhoeae_ among female sex


workers, Republic of the Philippines, 1996–1997. _J. Infect. Dis._ 179, 729–733 (1999). Article  CAS  Google Scholar  * Dong, H. V. et al. Decreased cephalosporin susceptibility of


oropharyngeal neisseria species in antibiotic-using men-who-have-sex-with-men of Hanoi, Vietnam. _Clin. Infect. Dis_. https://doi.org/10.1093/cid/ciz365 (2019). * Igawa, G. et al. _Neisseria


cinerea_ with high ceftriaxone MIC is a source of ceftriaxone and cefixime resistance-mediating penA sequences in _Neisseria gonorrhoeae_. _Antimicrob. Agents Chemother._ 62, e02069–17


(2018). Article  Google Scholar  * Holloway, K. A., Rosella, L. & Henry, D. The impact of WHO essential medicines policies on inappropriate use of antibiotics. _PLOS ONE_ 11, e0152020


(2016). Article  Google Scholar  * Taylor, S. N. et al. Single-dose zoliflodacin (ETX0914) for treatment of urogenital gonorrhea. _N. Engl. J. Med._ 379, 1835–1845 (2018). Article  CAS 


Google Scholar  * Allen, G. P. & Hankins, C. D. Evaluation of the mutant selection window for fluoroquinolones against _Neisseria gonorrhoeae_. _J. Antimicrob. Chemother._ 64, 359–363


(2009). Article  CAS  Google Scholar  * Allan-Blitz, L.-T. et al. Implementation of a rapid genotypic assay to promote targeted ciprofloxacin therapy of _Neisseria gonorrhoeae_ in a large


health system. _Clin. Infect. Dis._ 64, 1268–1270 (2016). PubMed Central  Google Scholar  * Deng, X., Allan-Blitz, L.-T. & Klausner, J. D. Using the genetic characteristics of _Neisseria


gonorrhoeae_ strains with decreased susceptibility to cefixime to develop a molecular assay to predict cefixime susceptibility. _Sex. Health_


https://www.publish.csiro.au/SH/justaccepted/SH18227 (2019). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Charles R. Drew University of Medicine


and Science, Los Angeles, CA, USA Huan V. Dong * Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Huan V. Dong & Jeffrey D. Klausner *


Department of Epidemiology, Fielding School of Public Health at UCLA, Los Angeles, CA, USA Jeffrey D. Klausner Authors * Huan V. Dong View author publications You can also search for this


author inPubMed Google Scholar * Jeffrey D. Klausner View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jeffrey D.


Klausner. ETHICS DECLARATIONS COMPETING INTERESTS J.D.K. has received advisory fees or research support from SpeedX Diagnostics, Shield Diagnostics, Hologic and Cepheid. H.V.D. declares no


competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dong, H.V., Klausner, J.D. _Neisseria gonorrhoeae_ resistance driven by antibiotic


use. _Nat Rev Urol_ 16, 509–510 (2019). https://doi.org/10.1038/s41585-019-0206-2 Download citation * Published: 10 June 2019 * Issue Date: September 2019 * DOI:


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