PRIME suspects in RA flares | Nature Reviews Rheumatology

Access through your institution Buy or subscribe Rheumatoid arthritis (RA) is characterized by recurrent flares in disease activity, yet relatively little is known about the physiological

events that precede a flare. A new study published in _The New England Journal of Medicine_ provides evidence for immune alterations that occur 2 weeks ahead of a flare and suggests a new

cellular culprit in flare initiation. The research team identified gene expression signatures associated with myeloid cells, neutrophils and platelets during the flares themselves, and

another signature associated with naive B cells in samples taken 2 weeks before a flare. Intriguingly, a gene expression signature strongly emerged in samples taken 1 week before a flare

that was reminiscent of mesenchymal cells. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other

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D. E. et al. RNA identification of PRIME cells predicting rheumatoid arthritis flares. _N. Engl. J. Med._ 383, 218–228 (2020) Article  CAS  Google Scholar  Download references AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Joanna Clarke Authors * Joanna Clarke View author publications You can also search for this

author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joanna Clarke. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Clarke, J. PRIME

suspects in RA flares. _Nat Rev Rheumatol_ 16, 472 (2020). https://doi.org/10.1038/s41584-020-0483-4 Download citation * Published: 28 July 2020 * Issue Date: September 2020 * DOI:

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