Synovial macrophage populations linked to ra remission

Access through your institution Buy or subscribe Sustained drug-free remission is an important but rarely achieved clinical state in patients with rheumatoid arthritis (RA). A better

understanding of the mechanisms underlying drug-free remission in RA could lead to improved treatment strategies. New findings suggest that particular populations of macrophages residing in

the synovial tissue have pro-resolving functions, which might provide important clues and targets for restoring synovial homeostasis. Using single cell RNA sequencing (scRNA-seq), the

researchers characterized the STM populations present in the healthy synovium, in the inflamed synovium of patients with active RA and in the synovium of patients with RA in sustained

disease remission. They identified two main STM populations: MerTKneg and MerTKpos STMs. These two populations contained four and five distinct phenotypic clusters, respectively. This is a

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Alivernini, S. et al. Distinct synovial tissue macrophage subsets

regulate inflammation and remission in rheumatoid arthritis. _Nat. Med._ https://doi.org/10.1038/s41591-020-0939-8 (2020) Article  PubMed  Google Scholar  Download references AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Jessica McHugh Authors * Jessica McHugh View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jessica McHugh. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McHugh, J.

Synovial macrophage populations linked to RA remission. _Nat Rev Rheumatol_ 16, 471 (2020). https://doi.org/10.1038/s41584-020-0481-6 Download citation * Published: 23 July 2020 * Issue

Date: September 2020 * DOI: https://doi.org/10.1038/s41584-020-0481-6 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,

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