Induced treg cells stay on course

Access through your institution Buy or subscribe Regulatory T (Treg) cells are important for preventing autoimmunity and are typically divided into two subgroups: natural Treg (nTreg) cells

and induced Treg (iTreg) cells. New findings published in _Science Advances_ suggest that iTreg cells, but not nTreg cells, maintain their regulatory function after exposure to arthritic

conditions, which could have implications for Treg cell-based therapies in autoimmune conditions such as rheumatoid arthritis (RA). The authors on this latest study decided to take these

investigations further by comparing the responses of nTreg cells and iTreg cells under similar conditions. In co-cultures with synovial fibroblasts from mice with CIA (inflamed synovial

fibroblasts), iTreg cells, but not nTreg cells, retained their FOXP3 expression and suppressive capacity, whereas some nTreg cells transdifferentiated into TH17 cells, concurring with

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Yang, S. et al. Induced, but not

natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts. _Sci. Adv._ 6, eabb0606 (2020) Article  CAS  Google Scholar  Download

references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Jessica McHugh Authors * Jessica McHugh View author publications You can

also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jessica McHugh. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE McHugh, J. Induced Treg cells stay on course. _Nat Rev Rheumatol_ 17, 2 (2021). https://doi.org/10.1038/s41584-020-00558-y Download citation * Published: 01 December 2020 * Issue

Date: January 2021 * DOI: https://doi.org/10.1038/s41584-020-00558-y SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,

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