Myelin damage links brain ageing to amyloid-β deposition

Access through your institution Buy or subscribe Loss of myelin integrity, which occurs during ageing, promotes deposition of amyloid-β (Aβ) in the brain, according to new research published

in _Nature_. Aβ plaques are an important pathological hallmark of Alzheimer disease (AD), and the findings provide mechanistic insights to help to explain why the risk of AD increases with

age. The researchers used mouse models of AD to investigate the relationship between myelin dysfunction and Aβ burden. To overcome the challenge of modelling ageing-related changes in

animals with such short lifespans, the AD mice were crossed with other mouse lines that were genetically predisposed to develop myelin defects at an early age. This is a preview of

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Depp, C. et al. Myelin dysfunction drives amyloid-β deposition in

models of Alzheimer’s disease. _Nature_ 618, 349–357 (2023) Article  CAS  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature

Reviews Neurology http://www.nature.com/nrneurol/ Heather Wood Authors * Heather Wood View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to Heather Wood. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wood, H. Myelin damage links brain ageing to amyloid-β deposition.

_Nat Rev Neurol_ 19, 457 (2023). https://doi.org/10.1038/s41582-023-00843-w Download citation * Published: 19 June 2023 * Issue Date: August 2023 * DOI:

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