Microglial transcriptional changes in ad

Access through your institution Buy or subscribe Through the use of single-nucleus RNA sequencing, researchers have identified Alzheimer disease (AD)-specific transcriptional profiles in

post-mortem human microglia. In addition to confirming the presence of previously established microglial phenotypes, the study identified novel microglial clusters that expressed genes

associated with the endolysosomal network. This experimental approach could provide important insights into the role of microglial transcriptomic changes in AD and possibly aid the

development of new therapeutic strategies for this condition. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access

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ARTICLE * Prater, K. E. et al. Human microglia show unique transcriptional changes in Alzheimer’s disease. _Nat. Aging_ https://doi.org/10.1038/s43587-023-00424-y (2023) Article  PubMed 

Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology http://www.nature.com/nrneurol/ Heather Wood Authors * Heather Wood View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Heather Wood. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Wood, H. Microglial transcriptional changes in AD. _Nat Rev Neurol_ 19, 387 (2023). https://doi.org/10.1038/s41582-023-00835-w Download citation * Published: 06

June 2023 * Issue Date: July 2023 * DOI: https://doi.org/10.1038/s41582-023-00835-w SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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