Exosomes can spread toxic ad pathology

Access through your institution Buy or subscribe Previous work has demonstrated that Aβ pathology can be propagated from cell to cell in a prion-like manner. However, the mechanism by which

Aβ is transferred between cells is not known. In their new study, Martin Hallbeck and colleagues investigated whether exosomes have a role in the transfer of toxic Aβ oligomers (oAβ).

“Exosomes are made from endosomes and we knew from our earlier research that intracellular toxic aggregates of Aβ often end up in the endosomal system,” explains Hallbeck. “From this, we

speculated that the aggregates could end up in exosomes and thus hitch a ride to the next cell.” This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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support REFERENCES ORIGINAL ARTICLE * Sinha, M. S. et al. Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers. _Acta Neuropathol._

https://doi.org/10.1007/s00401-018-1868-1 (2018) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology

http://www.nature.com/nrneurol/ Ian Fyfe Authors * Ian Fyfe View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ian

Fyfe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fyfe, I. Exosomes can spread toxic AD pathology. _Nat Rev Neurol_ 14, 451 (2018).

https://doi.org/10.1038/s41582-018-0039-2 Download citation * Published: 22 June 2018 * Issue Date: August 2018 * DOI: https://doi.org/10.1038/s41582-018-0039-2 SHARE THIS ARTICLE Anyone you

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