Retinal implants show promise in macular degeneration

Access through your institution Buy or subscribe “Past studies indicate that stem cell-derived RPE cells are a viable option as a cell replacement therapy for macular degeneration,” comments

Amir H. Kashani, the first author of the _Science Translational Medicine_ paper. “Our proposed treatment — a polarized monolayer of RPE cells on a synthetic scaffold — was designed with the

intent to replace atrophic or missing RPE cells in patients with advanced dry AMD.” For their trial, Kashani and colleagues recruited five patients with advanced dry AMD. The team used a

retinal implant known as CPCB-RPE1, which consists of human embryonic stem cell (hESC)-derived RPE cells on a synthetic parylene substrate. The implantation procedure was successfully

completed in four of the five participants. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Kashani,

A. H. et al. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. _Sci. Transl Med._ 10, eaao4097 (2018) Article  PubMed  Google Scholar

  * da Cruz, L. et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. _Nat. Biotechnol_.

https://doi.org/10.1038/nbt.4114 (2018) Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neurology http://www.nature.com/nrneurol/ Heather Wood Authors *

Heather Wood View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Heather Wood. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wood, H. Retinal implants show promise in macular degeneration. _Nat Rev Neurol_ 14, 317 (2018). https://doi.org/10.1038/s41582-018-0007-x

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