The dynamic lung microbiome in health and disease

ABSTRACT New methods and technologies within the field of lung biology are beginning to shed new light into the microbial world of the respiratory tract. Long considered to be a sterile

environment, it is now clear that the human lungs are frequently exposed to live microbes and their by-products. The nature of the lung microbiome is quite distinct from other microbial

communities inhabiting our bodies such as those in the gut. Notably, the microbiome of the lung exhibits a low biomass and is dominated by dynamic fluxes of microbial immigration and

clearance, resulting in a bacterial burden and microbiome composition that is fluid in nature rather than fixed. As our understanding of the microbial ecology of the lung improves, it is

becoming increasingly apparent that certain disease states can disrupt the microbial–host interface and ultimately affect disease pathogenesis. In this Review, we provide an overview of

lower airway microbial dynamics in health and disease and discuss future work that is required to uncover novel therapeutic targets to improve lung health. Access through your institution

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INTO THE PATHOGENESIS OF RESPIRATORY DISEASES Article Open access 17 January 2024 LUNG MICROBIAL-HOST INTERFACE THROUGH THE LENS OF MULTI-OMICS Article 06 July 2022 A PREVALENT AND

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1037–1045 (2008). Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by grant R37 CA244775 (LNS, NCI/NIH). AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA Jake G. Natalini, Shivani

Singh & Leopoldo N. Segal * NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA Jake G. Natalini Authors * Jake G. Natalini View author publications You can also

search for this author inPubMed Google Scholar * Shivani Singh View author publications You can also search for this author inPubMed Google Scholar * Leopoldo N. Segal View author

publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS The authors contributed equally to all aspects of the article. CORRESPONDING AUTHOR Correspondence to

Leopoldo N. Segal. ETHICS DECLARATIONS COMPETING INTERESTS All authors declare no competing interests. PEER REVIEW PEER REVIEW INFORMATION _Nature Reviews Microbiology_ thanks Christopher

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lung microbiome in health and disease. _Nat Rev Microbiol_ 21, 222–235 (2023). https://doi.org/10.1038/s41579-022-00821-x Download citation * Accepted: 17 October 2022 * Published: 16

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