Double (mtRNA) trouble | Nature Reviews Immunology

Access through your institution Buy or subscribe Sequestration and metabolism of host nucleic acids is important for preventing the aberrant activation of cytosolic innate immune sensors.

Various studies have identified key pathways that prevent mitochondrial DNA (mtDNA) from escaping into the cytoplasm; Nicholas Proudfoot and colleagues now describe key roles for the RNA

degradasome components SUV3 and polynucleotide phosphorylase (PNPase, encoded by _PNPT1_) in preventing the accumulation of mitochondrial double-stranded RNA (mtdsRNA). Inhibition of

mitochondrial transcription led to a rapid loss of mtdsRNA, and in small interfering RNA (siRNA)-mediated depletion experiments, the authors identified key roles for the helicase SUV3 and

for PNPase in preventing dsRNA accumulation. Further studies suggested that the unwinding activity of SUV3 and exonuclease activity of PNPase are important for limiting dsRNA levels in

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Dhir, A. et al. Mitochondrial double-stranded RNA

triggers antiviral signalling in humans. _Nature_ 560, 238–242 (2018) Article  PubMed  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews

Immunology http://www.nature.com/nri/ Yvonne Bordon Authors * Yvonne Bordon View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Yvonne Bordon. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bordon, Y. Double (mtRNA) trouble. _Nat Rev Immunol_ 18, 543 (2018).

https://doi.org/10.1038/s41577-018-0055-x Download citation * Published: 13 August 2018 * Issue Date: September 2018 * DOI: https://doi.org/10.1038/s41577-018-0055-x SHARE THIS ARTICLE

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