Prognostic potential of repeated faecal haemoglobin levels in crc detection

Access through your institution Buy or subscribe Repeated faecal haemoglobin (F-Hb) level measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) have

prognostic potential, according to a new study. 265,881 participants completed three rounds of FIT, with negative test results in rounds 1 and 2 and colonoscopy follow-up for those with

positive FIT. 3.3% (8,806) of participants had a positive FIT, with advanced neoplasia detected in 1.2% (3,254) and CRC in 0.2% (557). F-Hb concentrations in rounds 1 and 2 of FIT screening

were the strongest outcome predictors, with risk predictions matching the observed risk for the majority of participants. Prognostic models based on age, sex and F-Hb concentrations during

successive FIT rounds could predict future advanced neoplasia or CRC. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

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REFERENCES ORIGINAL ARTICLE * Meester, R. G. S. et al. Faecal occult blood loss accurately predicts future detection of colorectal cancer. A prognostic model. _Gut_

https://doi.org/10.1136/gutjnl-2022-327188 (2022) Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Gastroenterology &

Hepatology http://www.nature.com/nrgastro/ Katrina Ray Authors * Katrina Ray View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Katrina Ray. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ray, K. Prognostic potential of repeated faecal haemoglobin levels in CRC

detection. _Nat Rev Gastroenterol Hepatol_ 19, 416 (2022). https://doi.org/10.1038/s41575-022-00639-1 Download citation * Published: 06 June 2022 * Issue Date: July 2022 * DOI:

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