Smart delivery of vaccines | Nature Materials

A strategy to enhance antigen immunogenicity was developed by adsorption of polyethyleneimine on a mesoporous silica microrod vaccine for the presentation of tumour viruses and neoantigens,

demonstrating their ability to drive anti-tumour immunity. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Learn

more Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to

full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our

FAQs * Contact customer support REFERENCES * Melief, C. J. M., van Hall, T., Arens, R., Ossendorp, F. & van der Burg, S. H. _J. Clin. Invest._ 125, 3401–3412 (2015). Article  Google

Scholar  * Ott, P. A. et al. _Nature_ 547, 217–220 (2017). Article  Google Scholar  * Sahin, U. et al. _Nature_ 547, 222–226 (2017). Article  Google Scholar  * van Duikeren, S. et al. _J.

Immunol._ 189, 3397–3403 (2012). Article  Google Scholar  * Li, A. W. et al. _Nat. Mater._ https://doi.org/10.1038/s41563-018-0028-2 (2018). Google Scholar  * Kim, J. et al. _Nat.

Biotechnol._ 33, 64–72 (2015). Article  Google Scholar  * Eickhoff, S. et al. _Cell_ 162, 1322–1337 (2015). Article  Google Scholar  * Gerner, M. Y., Casey, K. A., Kastenmuller, W. &

Germain, R. N. _J. Exp. Med._ 214, 3105–3122 (2017). Article  Google Scholar  * Moynihan, K. D. et al. _Nat. Med._ 22, 1402–1410 (2016). Article  Google Scholar  * van der Burg, S. H.,

Arens, R., Ossendorp, F., van Hall, T. & Melief, C. J. M. _Nat. Rev. Cancer_ 16, 219–233 (2016). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS

* Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands Cornelis J. M. Melief * ISA Pharmaceuticals, Leiden, the Netherlands

Cornelis J. M. Melief Authors * Cornelis J. M. Melief View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Cornelis J.

M. Melief. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Melief, C.J.M. Smart delivery of vaccines. _Nature Mater_ 17, 482–483 (2018).

https://doi.org/10.1038/s41563-018-0085-6 Download citation * Published: 23 May 2018 * Issue Date: June 2018 * DOI: https://doi.org/10.1038/s41563-018-0085-6 SHARE THIS ARTICLE Anyone you

share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the

Springer Nature SharedIt content-sharing initiative