Chromatin replication and epigenetic cell memory

ABSTRACT Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and

the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation

impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.

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OTHERS PARENTAL NUCLEOSOME SEGREGATION AND THE INHERITANCE OF CELLULAR IDENTITY Article 26 January 2021 SYMMETRIC INHERITANCE OF PARENTAL HISTONES GOVERNS EPIGENOME MAINTENANCE AND EMBRYONIC

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PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS K.R.S.-M. is supported by a postdoctoral fellowship from the Lundbeck Foundation and a Marie Curie Individual

Fellowship (MSCA-IF-2016 no. 747332). Research in the Groth laboratory is supported by the Lundbeck Foundation (R198-2015-269), the European Research Council (ERC CoG no. 724436),

Independent Research Fund Denmark (7016-00042B; 4092-00404B), the Novo Nordisk Foundation (NNF14CC0001; NNF14OC0012839), the NEYE foundation and the Danish Cancer Society. AUTHOR INFORMATION

Author notes * Nataliya Petryk Present address: Epigenetics and Cell Fate, UMR7216 CNRS, University of Paris, Paris, France AUTHORS AND AFFILIATIONS * The Novo Nordisk Foundation Center for

Protein Research (CPR), University of Copenhagen, Copenhagen, Denmark Kathleen R. Stewart-Morgan & Anja Groth * Biotech Research and Innovation Centre (BRIC), University of Copenhagen,

Copenhagen, Denmark Kathleen R. Stewart-Morgan, Nataliya Petryk & Anja Groth Authors * Kathleen R. Stewart-Morgan View author publications You can also search for this author inPubMed 

Google Scholar * Nataliya Petryk View author publications You can also search for this author inPubMed Google Scholar * Anja Groth View author publications You can also search for this

author inPubMed Google Scholar CONTRIBUTIONS K.R.S.-M., N.P. and A.G. conceived, prepared figures for and wrote the manuscript. CORRESPONDING AUTHOR Correspondence to Anja Groth. ETHICS

DECLARATIONS COMPETING INTERESTS A.G. is CSO and co-founder of Ankrin Therapeutics. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional

claims in published maps and institutional affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stewart-Morgan, K.R., Petryk, N. & Groth, A.

Chromatin replication and epigenetic cell memory. _Nat Cell Biol_ 22, 361–371 (2020). https://doi.org/10.1038/s41556-020-0487-y Download citation * Received: 12 September 2019 * Accepted:

18 February 2020 * Published: 30 March 2020 * Issue Date: April 2020 * DOI: https://doi.org/10.1038/s41556-020-0487-y SHARE THIS ARTICLE Anyone you share the following link with will be able

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