Role of proteins in the degradation of relatively inert alloys in the human body
Role of proteins in the degradation of relatively inert alloys in the human body"
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Many biomedical materials used today for applications such as orthopedic, dental, and cardiovascular implants and devices are made of corrosion-resistant, ‘inert’, metallic materials of the
cobalt–chromium, titanium, and stainless steel alloy groups. This perspective focuses on the role of proteins in the degradation of these materials in a human body environment. After
adsorption, the proteins interact relatively slowly with the metal and metal surface oxide. A number of factors, including the individual body chemistry (especially the presence of
inflammatory cells producing oxidative species), determine whether the proteins can bind to metals in the surface oxide and whether the metal–protein conjugates can detach from the surface.
Metals in the forms of protein-bound metal ions or nanosized particles can also increase protein–protein interactions and aggregation, which can cause some health effects and change the
material degradation mechanism. While proteins in some short-term studies (
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