Predictors of 25-hydroxyvitamin d concentrations during pregnancy: a longitudinal analysis in the brazilian amazon

ABSTRACT OBJECTIVES To determine predictors of 25-hydroxyvitamin D3 (25(OH)D3) concentrations (25th, 50th, and 75th percentiles) in the third trimester of pregnancy. SUBJECTS/METHODS Data on

sociodemographic, obstetric, lifestyle and pregnancy characteristics, including serum 25(OH)D3 and retinol, were collected among 448 pregnant women who participated in the Maternal and

Child Health and Nutrition in Acre, Brazil (MINA-Brazil Study) in Cruzeiro do Sul, Brazilian Amazon (latitude 7°S). Simultaneous-quantile regression was fitted to prospectively assess

predictors at the 25th, 50th and 75th percentiles of 25(OH)D3 concentrations. RESULTS In the third trimester, 25(OH)D3 <50 nmol/L was observed in 26% of pregnant women. Exposure to the

Amazonian dry season during follow-up and vitamin D status ≥75 nmol/L in the second trimester of pregnancy were positively associated with 25(OH)D3 concentrations in the third trimester.

Pregnant women who were the main providers of family income presented lower 25(OH)D3 concentrations (50th and 75th percentiles: −15 nmol/L, 95%CI −24; −3, _p_ = 0.02, and −22 nmol/L, 95%CI

−36; −7, _p_ = 0.004, respectively), as well as those with sustained vitamin A insufficiency (25th and 50th percentiles: −27 nmol/L, 95%CI −40; −15, _p_ < 0.001, and −17 nmol/L, 95%CI

−33; −1, _p_ = 0.04, respectively). Sun protection practices had a smaller negative impact on 25(OH)D3, restricted to participants whose concentrations were at the 25th percentile of the

distribution. CONCLUSIONS Seasonality and vitamin A status were important predictors of 25(OH)D3 concentrations in the third trimester. Adequate exposure to sunlight and dietary sources of

vitamin A within safe intake levels may help ensuring a good nutritional status of vitamin D during pregnancy. Access through your institution Buy or subscribe This is a preview of

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NON-PREGNANT WOMEN OF REPRODUCTIVE AGE: A STUDY IN SOUTHERN THAILAND Article Open access 14 September 2023 PREVALENCE AND RISK FACTORS OF HYPOVITAMINOSIS D IN PREGNANT SPANISH WOMEN Article

Open access 25 September 2020 OPPOSITE CORRELATION OF 25-HYDROXY-VITAMIN D- AND 1,25-DIHYDROXY-VITAMIN D-METABOLITES WITH GESTATIONAL AGE, BONE- AND LIPID-BIOMARKERS IN PREGNANT WOMEN

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Download references ACKNOWLEDGEMENTS The authors thank all the participants and health professionals involved in the study, as well as the State Health Secretariat of Acre, the Municipal

Health Secretariat, the Primary Health Care Units of Cruzeiro do Sul. FUNDING This work is part of the MINA-Brazil Study, which was funded by the São Paulo Research Foundation (FAPESP grant

2016/00270-6; PI: MAC) and the Brazilian National Council for Scientific and Technological Development (CNPq grant 407255/2013-3; PI: MAC). CZR and TCC received scholarships from the

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES Finance Code 001). MAC is recipient of a senior research scholarship from CNPq. Organisations involved in the

financial support of this work had no role in the design, analysis, or writing of this article. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Public Health Nutrition Program, School of

Public Health, University of São Paulo, São Paulo, Brazil Caroline Zani Rodrigues, Thaís Carlos Correia & Paulo Augusto Ribeiro Neves * Postgraduate Program in Epidemiology, School of

Medicine, Federal University of Pelotas, Pelotas, Brazil Paulo Augusto Ribeiro Neves * Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil Maíra

Barreto Malta, Marly Augusto Cardoso & Bárbara Hatzlhoffer Lourenço * Postgraduate Program in Public Health, Catholic University of Santos, Santos, Brazil Maíra Barreto Malta Authors *

Caroline Zani Rodrigues View author publications You can also search for this author inPubMed Google Scholar * Thaís Carlos Correia View author publications You can also search for this

author inPubMed Google Scholar * Paulo Augusto Ribeiro Neves View author publications You can also search for this author inPubMed Google Scholar * Maíra Barreto Malta View author

publications You can also search for this author inPubMed Google Scholar * Marly Augusto Cardoso View author publications You can also search for this author inPubMed Google Scholar *

Bárbara Hatzlhoffer Lourenço View author publications You can also search for this author inPubMed Google Scholar CONSORTIA MINA-BRAZIL STUDY GROUP CONTRIBUTIONS CZR, TCC, and BHL conceived

the analytical framework and performed the statistical analysis. PARN, MBM, MAC, and BHL participated in data collection and field overseen. MAC and BHL conceived the study design and

methods. MAC was responsible for funding acquisition and project administration. CZR and TCC wrote the first draft of the paper, with critical appraisal by BHL. All authors reviewed and

approved the final version of the paper. CORRESPONDING AUTHOR Correspondence to Bárbara Hatzlhoffer Lourenço. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. ETHICAL APPROVAL This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving participants were approved by the

Institutional Review Board of the School of Public Health of the University of São Paulo (protocol number 872.613/2014). Written informed consent was obtained from all participants. In case

of teenage pregnancies, the adolescent’s legal guardian provided consent. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in

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CITE THIS ARTICLE Rodrigues, C.Z., Correia, T.C., Neves, P.A.R. _et al._ Predictors of 25-hydroxyvitamin D concentrations during pregnancy: A longitudinal analysis in the Brazilian Amazon.

_Eur J Clin Nutr_ 76, 1281–1288 (2022). https://doi.org/10.1038/s41430-022-01102-9 Download citation * Received: 23 September 2021 * Revised: 03 February 2022 * Accepted: 07 February 2022 *

Published: 21 February 2022 * Issue Date: September 2022 * DOI: https://doi.org/10.1038/s41430-022-01102-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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