Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus

ABSTRACT A library of 18 structurally diverse semisynthetic lupane, oleanane, and ursane types triterpenoids, including C19- or C28-(1,2,3-triazolyl)- and aminomethylated derivatives

obtained by the «click» reaction with various aromatic and sugar azides or by Mannich reaction with secondary amines, were tested for antiviral activity against HCMV, HSV-1, and HPV-11

types. C28-Triazolyl-derivative with a benzyl substituent of 2,3-indolo-oleanolic acid was the most active against the HCMV virus with EC50 < 0.05 (SI > 81). Lupane

3,28-diacetoxy-triazolyl derivatives with phenyl- and fluorophenyl-fragments possess the highest activity among all screened compounds toward HPV-11 type virus with EC50 values of 2.97 µM

and 1.20 μM, SI90 values of 28 and >125, respectively. One can see that modification of triterpenic alkynes to Mannich bases was more efficient in increasing an activity against HSV-1

than their conversion to triazoles. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS AZEPANODIPTEROCARPOL IS POTENTIAL CANDIDATE FOR INHIBITS INFLUENZA H1N1 TYPE AMONG OTHER LUPANE, OLEANANE, AND

DAMMARANE A-RING AMINO-TRITERPENOIDS Article 04 March 2022 EVALUATION OF A-RING HYDROXYMETHYLENE-AMINO- TRITERPENOIDS AS INHIBITORS OF SARS-COV-2 SPIKE PSEUDOVIRUS AND INFLUENZA H1N1

Article 24 November 2023 EVALUATION OF A-AZEPANO-TRITERPENOIDS AND RELATED DERIVATIVES AS ANTIMICROBIAL AND ANTIVIRAL AGENTS Article 12 July 2021 REFERENCES * Dzubak P, Hajduch M, Vydra D,

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references ACKNOWLEDGEMENTS This work was supported by the Federal program No. 1021062311392-9-1.4.1. The study of antiviral activity was funded in whole or in part with Federal funds from

the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract HHSN272201100016I (MNP). AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054, Ufa, Russian Federation Elmira F.

Khusnutdinova, Anastasiya V. Petrova & Oxana B. Kazakova Authors * Elmira F. Khusnutdinova View author publications You can also search for this author inPubMed Google Scholar *

Anastasiya V. Petrova View author publications You can also search for this author inPubMed Google Scholar * Oxana B. Kazakova View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Elmira F. Khusnutdinova. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare no competing interests. ADDITIONAL

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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Khusnutdinova, E.F., Petrova, A.V. & Kazakova, O.B. Antiviral potency of lupane and oleanane alkynyl-derivatives against human

cytomegalovirus and papillomavirus. _J Antibiot_ 77, 50–56 (2024). https://doi.org/10.1038/s41429-023-00672-5 Download citation * Received: 18 April 2023 * Revised: 26 September 2023 *

Accepted: 03 October 2023 * Published: 07 November 2023 * Issue Date: January 2024 * DOI: https://doi.org/10.1038/s41429-023-00672-5 SHARE THIS ARTICLE Anyone you share the following link

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