Fact, overdiagnosis cannot be evaluated by comparing histological grading of prostate biopsy to prostatectomy specimen

Access through your institution Buy or subscribe Martini A., Touzani A., Mazzone E., Roumiguié M., Marra G., Valerio M., et al. state that the use of targeted biopsies has recently been

under scrutiny [1]. In our opinion, the analysis, and the conclusion of limited downgrading from multiparametric MRI biopsies to radical prostatectomy (RP) specimen does not change that [1].

It is interesting to study the grade and stage migration, however, this has nothing to do with evaluating the risk of overdiagnosis. The authors show that ISUP 2 histological grade obtained

by multiparametric MRI biopsies targeted to the cancerous lesion is seldomly downgraded when compared with the RP specimen and suggest that MRI targeting does not lead to overdiagnosis [1].

Overdiagnosis is a term used to describe men who are diagnosed with a disease that will never develop into symptoms or death, which is not reported here. Moreover, some aspects of the

article need of clarification. The authors state that the men included had no prior biopsies, however, in the Table, 210 men are reported with one or more prior biopsies. Furthermore, among

the men with ISUP 2 on RP pathology, 60% is reported as pT0, indicating no cancer found in the specimen, and an additional 32% is reported with pT1, both findings need clarification. This is

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Martini A, Touzani A, Mazzone E,

Roumiguié M, Marra G, Valerio M, et al. Overdiagnosis and stage migration of ISUP 2 disease due to mpMRI-targeted biopsy: facts or fictions. Prostate Cancer Prostatic Dis. 2022.

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2022;128:3674–3680. Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Copenhagen Prostate Cancer Center, Department of Urology, Center for

Cancer and Organ Disease - Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Hein Vincent Stroomberg, Klaus Brasso & Andreas Røder * Department of Public Health,

Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark Hein Vincent Stroomberg * Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Klaus Brasso 

& Andreas Røder Authors * Hein Vincent Stroomberg View author publications You can also search for this author inPubMed Google Scholar * Klaus Brasso View author publications You can

also search for this author inPubMed Google Scholar * Andreas Røder View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS Conceptualization: HVS,

KB, AR; Writing – Original Draft: HVS; Writing – Review & Editing: HVS, KB, AR. CORRESPONDING AUTHOR Correspondence to Hein Vincent Stroomberg. ETHICS DECLARATIONS COMPETING INTERESTS

The authors declare no competing interests. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional

affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stroomberg, H.V., Brasso, K. & Røder, A. Fact, overdiagnosis cannot be evaluated by

comparing histological grading of prostate biopsy to prostatectomy specimen. _Prostate Cancer Prostatic Dis_ 26, 804–805 (2023). https://doi.org/10.1038/s41391-022-00629-z Download citation

* Received: 11 November 2022 * Revised: 28 November 2022 * Accepted: 30 November 2022 * Published: 09 December 2022 * Issue Date: December 2023 * DOI:

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