Psmc6 induces immune cell infiltration and inflammatory response to aggravate primary sjögren’s syndrome

ABSTRACT Increasing evidence suggests that immune cell infiltration is involved in primary Sjögren’s syndrome (pSS), while the underlying molecular mechanisms remain elusive. Herein, this

study aims to explore the key molecular mechanism in immune cell infiltration in pSS based on Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were obtained,

followed by weighted gene co-expression network analysis to acquire the pSS-related module genes. Moreover, pSS-related DEGs and module genes were intersected. Additionally, the correlation

between key genes and immune cell infiltration was analyzed by CIBERSORT algorithm. Furthermore, pSS mouse models were established to explore the effects of PSMC6 on immune cell infiltration

and inflammatory responses in pSS. A total of 51 DEGs and 334 key module genes were involved in the occurrence of pSS. The immune cell infiltration was correlated with pSS, and PSMC6,

highly expressed in pSS samples, may be the key immune gene. In vivo animal experiments demonstrated that PSMC6 was upregulated in pSS, and PSMC6 knockdown could reduce lymphocytic

infiltration in salivary glands and lacrimal glands and the levels of related inflammatory factors in the pSS and increase the proportion of Treg cells. Collectively, PSMC6 could induce

immune cell infiltration and inflammatory responses to promote the occurrence of pSS, providing us with a potential therapeutic target for treating pSS. Access through your institution Buy

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OTHERS INVESTIGATING IMMUNE CELL INFILTRATION AND GENE EXPRESSION FEATURES IN PTERYGIUM PATHOGENESIS Article Open access 17 April 2025 GENE EXPRESSION ALTERATIONS IN SALIVARY GLAND EPITHELIA

OF SJÖGREN’S SYNDROME PATIENTS ARE ASSOCIATED WITH CLINICAL AND HISTOPATHOLOGICAL MANIFESTATIONS Article Open access 27 May 2021 GENOME-WIDE ASSOCIATION STUDY IDENTIFIES SJÖGREN’S RISK LOCI

WITH FUNCTIONAL IMPLICATIONS IN IMMUNE AND GLANDULAR CELLS Article Open access 27 July 2022 DATA AVAILABILITY The data underlying this article will be shared on reasonable request to the

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references FUNDING This study was funded by Chunhui Program of the Ministry of Education (z2010041), Natural Science Foundation of Heilongjiang Province (H2017064) and Project of

Heilongjiang Traditional Chinese Medicine Association (21102190004). AUTHOR INFORMATION Author notes * These authors contributed equally: Yongzhu Piao, Yutong Qi. AUTHORS AND AFFILIATIONS *

Department of Rheumatology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 150040, P. R. China Yongzhu Piao & Hao Zhang * Department of Rheumatology and

Immunology, Yancheng Chinese Medicine Hospital, Yancheng, 224000, P. R. China Yutong Qi * Department of Preventive Medicine, Beijing Longfu Hospital, Beijing, 100010, P. R. China Longyin Han

* Heilongjiang University of Chinese Medicine, Harbin, 150040, P. R. China Xiayuan Zhong & Qingnan Liu Authors * Yongzhu Piao View author publications You can also search for this

author inPubMed Google Scholar * Yutong Qi View author publications You can also search for this author inPubMed Google Scholar * Hao Zhang View author publications You can also search for

this author inPubMed Google Scholar * Longyin Han View author publications You can also search for this author inPubMed Google Scholar * Xiayuan Zhong View author publications You can also

search for this author inPubMed Google Scholar * Qingnan Liu View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS Conceived and designed the

experiments: YZP, YTQ. Performed experimental: HZ, LYH. Performed experimental validation: XYZ, QNL. Analyzed the data and conceived figures and tables: XYZ, QNL. Wrote the paper: YZP, YTQ.

Contributed to the writing of the manuscript: HZ, LYH. All authors revised and approved the final version of the manuscript. CORRESPONDING AUTHOR Correspondence to Yongzhu Piao. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in

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ARTICLE CITE THIS ARTICLE Piao, Y., Qi, Y., Zhang, H. _et al._ PSMC6 induces immune cell infiltration and inflammatory response to aggravate primary Sjögren’s syndrome. _J Hum Genet_ 68,

263–271 (2023). https://doi.org/10.1038/s10038-022-01107-z Download citation * Received: 03 August 2022 * Revised: 30 November 2022 * Accepted: 07 December 2022 * Published: 04 January 2023

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