Base deficit (bd) in babies with post-asphyxial hypoxic ischemic encephalopathy (pa-hie) and relationship to outcome 1107

Metabolic acidosis measured by BD reflects preceeding hypoxia. Umbilical arterial BD ≥16 mmol/L is considered consistent with risk of brain injury(Canadian Society of Obstetricians and

Gynecologists guideline). In severely asphyxiated newborns without cord blood gases, postnatal measurements may facilitate therapeutic decisions. OBJECTIVES: To describe BD changes in PA-HIE

during the first 6 hours after birth, correlate values with outcome, and estimate the effect of bicarbonate therapy on BD. METHODS: Retrospective observational study of a cohort of 280 term

infants with PA-HIE defined by modified ACOG criteria (Ekert P et al. J Pediatr 1997). Our admissions to 1 outborn and 2 perinatal centers represent a defined geographic region. Severe

adverse outcome was defined as death or severe neurologic impairment by age 12 m. The time course of postnatal BD was compared graphically between infants with and without severe adverse

outcome. In each outcome group, the BD time course was compared between bicarbonate treated(before the first postnatal blood gas) and untreated infants. RESULTS: Of 280 babies, 117 had

adverse outcome, 78 good outcome and 85 missing data. The graph shows BD with (upper line) and without adverse outcomes (lower line), and normal ranges. Bicarbonate treatment had no effect

on the course of BD. Figure AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada N Venkat Raju, Paul Ekert, Ashutosh Kumar 

& Max Perlman Authors * N Venkat Raju View author publications You can also search for this author inPubMed Google Scholar * Paul Ekert View author publications You can also search for

this author inPubMed Google Scholar * Ashutosh Kumar View author publications You can also search for this author inPubMed Google Scholar * Max Perlman View author publications You can also

search for this author inPubMed Google Scholar ADDITIONAL INFORMATION (Spon by: Hilary Whyte) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Raju, N.,

Ekert, P., Kumar, A. _et al._ Base Deficit (BD) in Babies with Post-asphyxial Hypoxic Ischemic Encephalopathy (PA-HIE) and relationship to Outcome 1107. _Pediatr Res_ 43 (Suppl 4), 190

(1998). https://doi.org/10.1203/00006450-199804001-01128 Download citation * Issue Date: 01 April 1998 * DOI: https://doi.org/10.1203/00006450-199804001-01128 SHARE THIS ARTICLE Anyone you

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