Maternal lifestyles study: patterns of cocaine use in term pregnancy and effect on birthweight. 1660

The impact of patterns of drug use during pregnancy on birthweight (BW) has not been reported. An objective of this study was to quantify history of drug use during pregnancy by a detailed

maternal inventory of substance use (MISU) and to assess relation between cocaine use and BW. Women at 4 sites (Brown U, U of Miami, U of Tenn Memphis, Wayne State U) with a history of

cocaine/opiate(C/O) use during pregnancy or presence of C/O metabolites in meconium (exposed(EXP) group n=538) were matched by race, GA and infant sex (comparison group(COM) n=731). The MISU

was administered at the 1 mo clinic visit. History of any substance use was assessed by 4 time periods: 3 mos prior to pregnancy, and during each trimester. Use was categorized as high

(daily or 3-6 d/wk), moderate (1-2 d/wk), low (1-3 d/mo) or none per time period. To assess the effect of cocaine on BW, cocaine use during 3 mo prior to pregnancy or first trimester was

compared with use in 2nd and 3rd trimesters among 245 women in EXP group and 412 in COM group who delivered at term. RESULTS: Tobacco, alcohol and marijuana use was noted in the COM group,

but use was significantly lower than EXP group (p<.05). Daily use during 1st and 3rd trimester was as follows: tobacco 65 & 59% in EXP and 25 & 19% in COM; alcohol 12 & 7% in

EXP and 2 & 0.6% in COM, marijuana 4 & 1% in EXP and 1 & 0.4% in COM. The effect of patterns of cocaine use on BW indicate COM infants were heavier (p<.01) than each of the

EXP groups. Table CONCLUSION: Cocaine EXP infants were lighter than COM infants; within EXP group there was no association between quantity of C use by the MISU during pregnancy and BW.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * NICHD Neonatal Research Network, Bethesda, MD., Seetha Shankaran, Charles R. Bauer, Henrietta S. Bada, Barry Lester, Linda L. Wright & 

Vasilas Katsikiotis Authors * Seetha Shankaran View author publications You can also search for this author inPubMed Google Scholar * Charles R. Bauer View author publications You can also

search for this author inPubMed Google Scholar * Henrietta S. Bada View author publications You can also search for this author inPubMed Google Scholar * Barry Lester View author

publications You can also search for this author inPubMed Google Scholar * Linda L. Wright View author publications You can also search for this author inPubMed Google Scholar * Vasilas

Katsikiotis View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Shankaran, S., Bauer, C., Bada, H. _et al._ MATERNAL LIFESTYLES STUDY: PATTERNS OF COCAINE USE IN TERM PREGNANCY AND EFFECT ON BIRTHWEIGHT. 1660. _Pediatr Res_ 39 (Suppl 4), 279 (1996).

https://doi.org/10.1203/00006450-199604001-01684 Download citation * Issue Date: 01 April 1996 * DOI: https://doi.org/10.1203/00006450-199604001-01684 SHARE THIS ARTICLE Anyone you share the

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