Malabsorption in infants with congenital heart disease under diuretic treatment

ABSTRACT ABSTRACT: Intestinal absorption and its relationship to increased total body water was studied in seven infants with congenital heart disease receiving regular diuretics due to

congestive heart failure. All infants and six age-matched healthy controls were studied for a 3-d period during which time all food intake was recorded, stools were collected, and total body

water content (TBW) and extracellular water were measured. All the anthropometric measurements were lower in the infants with congenital heart disease compared with healthy controls. Energy

and fat excretion in the stools were significantly increased in the group of patients, but when expressed as a percentage of daily caloric intake or as a percentage of the specific intake

(e.g. fat excretion/ fat intake ± 100), no statistical differences were found. TBW as a percentage of body weight was increased in our patients compared with our controls (84.95 o 5.82%

versus 68.65 ± 4.60%;p = 0.01) and so was extracellular water as a percentage of predicted (200.0 ± 18.6% versus 100.9 ± 7.2%; p = 0.001). A positive correlation was found between energy and

fat excretion as a percentage of the intake and TBW as a percentage of predicted; energy and fat malabsorption did not exceed 8% in the patients with the highest body water content (120% of

predicted). It is concluded that malabsorption is not a significant factor in failure to thrive of patients with congenital heart disease who are receiving regular diuretics. Based on the

significant negative correlation between excess body water and fat and calorie absorption, however, it is suggested to monitor TBW in patients who fail to gain weight. SIMILAR CONTENT BEING

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Article Open access 08 September 2020 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Pediatrics Department, Kaplan Hospital, Rehovot, Israel Nachum Vaisman & Matitiau Abraham

* Faculty of Agriculture, Rehovot, Israel Tirzah Leigh & Hillary Voet * The Soreq Nuclear Research Center, Yavne, Israel Roland Duchan * Department of Human Biology, University of

Limburg, Maastricht, The Netherlands Klaas Westerterp Authors * Nachum Vaisman View author publications You can also search for this author inPubMed Google Scholar * Tirzah Leigh View author

publications You can also search for this author inPubMed Google Scholar * Hillary Voet View author publications You can also search for this author inPubMed Google Scholar * Klaas

Westerterp View author publications You can also search for this author inPubMed Google Scholar * Matitiau Abraham View author publications You can also search for this author inPubMed 

Google Scholar * Roland Duchan View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Vaisman, N., Leigh, T., Voet, H. _et al._ Malabsorption in Infants with Congenital Heart Disease under Diuretic Treatment. _Pediatr Res_ 36, 545–549 (1994).

https://doi.org/10.1203/00006450-199410000-00023 Download citation * Received: 21 October 1993 * Accepted: 21 April 1994 * Issue Date: 01 October 1994 * DOI:

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