Compartmental analysis of calcium metabolism in very-low-birth-weight infants

ABSTRACT ABSTRACT: The calcium metabolism of 13 very-low-birth-weight infants fed a high-calcium diet was evaluated by means of stable isotope kinetic and balance studies. The studies used

orally and i.v. administered stable isotopes, and the kinetic data were evaluated with the aid of a sequential, three-compartment model. The infants (postmenstrual age 33 ± 1 wk, weight 1.34

± 0.03 kg) had higher bone calcium deposition rates (160 ± 7 mg·kg−1.d−1 or 4.00 ± 0.18 mmol·kg−1·d−1) than those previously reported for either older children or adults. Furthermore, when

analyzed as a function of net calcium absorption, bone calcium deposition rates increased markedly and significantly as net calcium absorption increased (r = 0.70, p < 0.01), whereas in

older individuals, bone calcium deposition is a relatively invariant function of absorption. A relatively smaller response of bone calcium removal to calcium absorption was found for the

very-low-birth-weight infants in this study (r = −0.39, p = 0.18), whereas in adults, bone calcium removal constitutes the major regulatory response. It is suggested that the calcium kinetic

results in the very-low-birth-weight infants reflect the high rate of bone growth typical of the third trimester of gestation. SIMILAR CONTENT BEING VIEWED BY OTHERS MATHEMATICAL MODELS FOR

PHOSPHATE KINETICS IN PATIENTS ON MAINTENANCE HEMODIALYSIS Article Open access 17 March 2025 THE ASSOCIATIONS BETWEEN SERUM TRACE ELEMENTS AND BONE MINERAL DENSITY IN CHILDREN UNDER 3 YEARS

OF AGE Article Open access 21 January 2021 HORMONAL REGULATION OF BIOMINERALIZATION Article 16 March 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics,

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine and Texas Children's Hospital, Houston,

77030, Texas Steven A Abrams & Richard J Schanler * Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development/National Institutes of

Health, Bethesda, 20892, Maryland Alfred L Yergey & Nancy E Vieira * Department of BioStructure and Function, University of Connecticut Health Center, Farmington, 06030, Connecticut

Felix Bronner Authors * Steven A Abrams View author publications You can also search for this author inPubMed Google Scholar * Richard J Schanler View author publications You can also search

for this author inPubMed Google Scholar * Alfred L Yergey View author publications You can also search for this author inPubMed Google Scholar * Nancy E Vieira View author publications You

can also search for this author inPubMed Google Scholar * Felix Bronner View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Abrams, S., Schanler, R., Yergey, A. _et al._ Compartmental Analysis of Calcium Metabolism in Very-Low-Birth-Weight Infants. _Pediatr

Res_ 36, 424–428 (1994). https://doi.org/10.1203/00006450-199410000-00002 Download citation * Received: 14 January 1994 * Accepted: 12 May 1994 * Issue Date: 01 October 1994 * DOI:

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