Longitudinal study of blood spot fsh concentrations in normal girls and turner syndrome during early postnatal life

ABSTRACT In different animal species, ovariectomy does not result in increased gonadotropin secretion in the fetus. In contrast, agonadal subjects show elevated FSH secretion during infancy.

Neonatal blood FSH levels were studied in 9 fullterm girls with Turner syndrome compared with phenotypically normal fullterm girls born the same week. We used blood spots collected at the

time of mass screening, 1 to 29 months prior to this study. FSH was measured using a highly specific immunoradionetric assay. On day 5-6 after birth, FSH was usually undetectable (< 1

mIU/ml) or low (1-3 mIU/ml) in normal girls. Among the 9 CD patients, 5 had FSH < 3 mIU/ml and 4 showed slightly elevated levels ranging 4.3-10.9 mIU/ml. These differences in FSH

secretion were not related to differences in karyotype. Among 5 patients sutided longitudinally, 3 showed increase in FSH levels to 14.9-15.9 mIU/ml during the second week of life. However,

this increase was comparable to that seen in 13 normal girls sampled on a second occasion 2-3 weeks after birth. One Turner patient had still low FSH (2.5 mIU/ml) on day 23 and showed some

increase to 8.5 mIU/ml on day 30. These data indicate that, in Turner patients. perinatal changes in FSH secretion are similar to normal girls though there is no feedback control by gonadal

hormones. Then, FSH assay cannot be used as a perinatal screening method for Turner syndrome in girls. Supported by a grant from the Belgian Study Group for Pediatric Endocrinology. ARTICLE

PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pedatries and Laboratory, Children's Hospital Reine Fabiola, University of Brussels, Medgenix, Belgium C Heinrichis, P

Bourdoux, C Saussez, H L Vis & J P Bomuguignon Authors * C Heinrichis View author publications You can also search for this author inPubMed Google Scholar * P Bourdoux View author

publications You can also search for this author inPubMed Google Scholar * C Saussez View author publications You can also search for this author inPubMed Google Scholar * H L Vis View

author publications You can also search for this author inPubMed Google Scholar * J P Bomuguignon View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Heinrichis, C., Bourdoux, P., Saussez, C. _et al._ LONGITUDINAL STUDY OF BLOOD SPOT FSH CONCENTRATIONS IN NORMAL

GIRLS AND TURNER SYNDROME DURING EARLY POSTNATAL LIFE. _Pediatr Res_ 33 (Suppl 5), S69 (1993). https://doi.org/10.1203/00006450-199305001-00398 Download citation * Issue Date: 01 May 1993 *

DOI: https://doi.org/10.1203/00006450-199305001-00398 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative