Developmental regulation of expression of c-reactive protein and serum amyloid a in syrian hamsters

ABSTRACT ABSTRACT: The fetal and maternal concentration of various plasma proteins alters during pregnancy. Cells in the livers of fetal hamsters accumulate serum amyloid A (SAA) and

C-reactive protein (CRP) mRNA, major acute phase reactants, when lipopolysaccharide is administered to the fetal circulation. No fetal SAA or CRP mRNA response is seen when the mother is

stimulated at a remote site by endotoxin or a nonspecific inflammatory agent. In addition, cells of the fetal hamster liver do not respond by accumulating SAA mRNA when exposed to the

specific cytokines, tumor necrosis factor, IL-1, and IL-6. CRP mRNA levels increased in fetal livers after administration of tumor necrosis factor and IL-1. These data suggest that cells

contained in the fetal liver can respond during an acute phase reaction but that the capacity of some acute phase reactant genes to respond to cytokines may be developmentally regulated.

Studies of immature hamsters after birth show that the responses of CRP and SAA genes to lipopolysaccharide, tumor necrosis factor, IL-1, and IL-6 are reduced when compared with induction of

mRNA accumulation for these acute phase reactants in adult animals. SIMILAR CONTENT BEING VIEWED BY OTHERS DEVELOPMENT OF THE IMMUNE SYSTEM IN THE HUMAN EMBRYO Article 18 January 2022

PRESENCE OF SERUM AMYLOID A3 IN MOUSE PLASMA IS DEPENDENT ON THE NATURE AND EXTENT OF THE INFLAMMATORY STIMULUS Article Open access 25 June 2020 THE SPECIFIC CONTRIBUTIONS OF FACTOR H AND

FACTOR I IN CONTROLLING FLUID PHASE ACTIVATION OF THE ALTERNATIVE COMPLEMENT PATHWAY Article Open access 29 March 2025 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Edward

Mallinckrodt Department of Pediatrics and James S. McDonnell Department of Genetics, Washington University School of Medicine, St Louis, 63110, Missouri S Bruce Dowton, Darrel J Waggoner 

& Kenneth D Mandl * the Harvard Medical School of Medicine, Boston, 02115, Massachusetts S Bruce Dowton, Darrel J Waggoner & Kenneth D Mandl Authors * S Bruce Dowton View author

publications You can also search for this author inPubMed Google Scholar * Darrel J Waggoner View author publications You can also search for this author inPubMed Google Scholar * Kenneth D

Mandl View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dowton, S.,

Waggoner, D. & Mandl, K. Developmental Regulation of Expression of C-Reactive Protein and Serum Amyloid A in Syrian Hamsters. _Pediatr Res_ 30, 444–449 (1991).

https://doi.org/10.1203/00006450-199111000-00010 Download citation * Issue Date: 01 November 1991 * DOI: https://doi.org/10.1203/00006450-199111000-00010 SHARE THIS ARTICLE Anyone you share

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