Xanthine oxidase during human fetal development

ABSTRACT ABSTRACT: Through oxygen free radical production, xanthine oxidase (XOD, E.C.1.2.3.2) has been implicated in the pathogenesis of postischemic and hyperoxic tissue injuries among

newborn. We measured the activity and evaluated the kinetic characteristics of XOD in human fetal liver, intestine, brain, and myocardium. Both the fetal liver and intestine contain a high

XOD activity through gestation. The activity increases in the liver and decreases in the intestine with advancing gestation. The apparent Km for hypoxanthine is 4.8–5.5 μM in the intestine

throughout gestation and in the liver at term but higher than 30 μM in the liver during the first half of pregnancy. The activity is undetectable both in the fetal brain and myocardium

throughout gestation. Thus, XOD activity is present at least in the liver and intestine to account for the oxidation of hypoxanthine and xanthine. However, direct evidence for adenine

nucleotide catabolism, followed by oxidation of the accumulated hypoxanthine during tissue reoxygenation in the human liver or intestine is not available. SIMILAR CONTENT BEING VIEWED BY

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ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Children's Hospital, University of Helsinki, SF-00290, Finland Kim Vettenranta & Kari O Raivio Authors * Kim Vettenranta

View author publications You can also search for this author inPubMed Google Scholar * Kari O Raivio View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vettenranta, K., Raivio, K. Xanthine Oxidase during Human Fetal Development. _Pediatr Res_ 27, 286–288

(1990). https://doi.org/10.1203/00006450-199003000-00017 Download citation * Received: 30 August 1989 * Accepted: 30 October 1989 * Issue Date: 01 March 1990 * DOI:

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