PLASMA ATRIAL NATRIURETIC PEPTIDE (ANP) AND CYCLIC GUANOSINE MONOPHOSPHATE (cGMP) LEVELS AND ANP-BINDING SITES ON PLATELETS IN THE PERINATAL PERIOD
PLASMA ATRIAL NATRIURETIC PEPTIDE (ANP) AND CYCLIC GUANOSINE MONOPHOSPHATE (cGMP) LEVELS AND ANP-BINDING SITES ON PLATELETS IN THE PERINATAL PERIOD"
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We reported higher plasma ANP-levels in newborns than in older children. It was speculated that elevated ANP-levels may result in a down-regulation of ANP-binding sites. To prove this
hypothesis we measured ANP together with the second messenger cGMP and ANP-binding sites on platelets in the perinatal period. Plasma ANP- and cGMP-levels were determined in mothers after
vaginal delivery (n=21) and after sectio (n=7) and in umbilical venous (n=27) and arterial (n=15) cord blood of term newborns. ANP-binding sites on platelets were determined in cord blood.
ANP- and cGMP-levels were significantly higher in mothers and in cord blood than in non-pregnant women (n=11) and in control infants beyond the neonatal period, resp. (n=18, p
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