Vitamin k1 content of maternal milk: influence of the stage of lactation, lipid composition, and vitamin k1 supplements given to the mother

ABSTRACT ABSTRACT. Using a sensitive electrochemical assay for vitamin K1 and standardized techniques for breast-milk collection, we studied the vitamin K1 content of human milk during the

first 5 wk of lactation with respect to 1) individual and interindividual differences, 2) the relationship of vitamin K1 to other lipids, and 3) the influence of oral supplements of vitamin

K1 on breast milk concentrations. Comparison of fore and hind milk from the mothers revealed higher vitamin K1 concentrations in hindmilks, suggesting that the lipid content influences the

vitamin K1 concentration in maternal milk. Samples of maternal milk from nine mothers collected from day 1 to day 36 of lactation showed significantly higher vitamin K1 concentrations in

colostral milk than in mature milk. For colostral milk there was a significant correlation of vitamin K1 to cholesterol (_r_ = 0.62) but not to total lipid or phospholipid suggesting a role

for cholesterol in the secretion of vitamin K1 into colostral milk. For mature milk correlation coefficients of vitamin K1 with all lipids were low (_r_ = 0.29- 0.37) suggesting that at

later stages of lactation dietary fluctuations of vitamin K1 may be a more important determinant of the vitamin K1 content of breast milk than the lipid composition. To test the influence of

diet, mothers were given oral supplements of vitamin K1. Doses of 0.5- 3 mg produced substantial rises in breast milk vitamin K1 with peak levels between 12 and 24 h. In one mother in whom

the milk sampling was standardized, a dose-response relationship was observed: the lowest dose of 100 μg was similar to that which might be ingested in a meal and produced a 2-fold increase

in the vitamin K1 content of breast milk. SIMILAR CONTENT BEING VIEWED BY OTHERS VITAMIN A CONCENTRATION IN BOVINE LIVER AND MILK DOES NOT ONLY DEPEND ON CHARACTERISTICS OF THE FARMING

SYSTEM Article Open access 17 March 2025 EVALUATION OF THE EFFECT OF DIFFERENT DIETS APPLIED TO BREASTFEEDING MOTHERS ON THE COMPOSITION AND QUANTITY OF HUMAN MILK Article Open access 10

March 2025 HUMAN MILK UNMETABOLIZED FOLIC ACID IS INCREASED FOLLOWING SUPPLEMENTATION WITH SYNTHETIC FOLIC ACID AS COMPARED TO (6_S_)-5-METHYLTETRAHYDROFOLIC ACID Article Open access 12 July

2023 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Universitäts-Kinderklinik Düsseldorf, West Germany Abt. für Neonatologie and Gastroenterologie, London, England R v Kries *

Universitäts-Kinderklinik Düsseldorf, West Germany Abt. für Hämalologie und Onkologie, London, England U Göbel * Department of Haemalology, Guy's Hospital and United Medical and Dental

Schools of Guy's and St. Thomas's Hospitals, London, England M Shearer & P T Mccarthy * Forschungsabteilung der Milupa AG, Friedrichsdorf, West Germany M Haug & G Harzer

Authors * R v Kries View author publications You can also search for this author inPubMed Google Scholar * M Shearer View author publications You can also search for this author inPubMed 

Google Scholar * P T Mccarthy View author publications You can also search for this author inPubMed Google Scholar * M Haug View author publications You can also search for this author

inPubMed Google Scholar * G Harzer View author publications You can also search for this author inPubMed Google Scholar * U Göbel View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kries, R., Shearer, M., Mccarthy, P. _et al._ Vitamin K1 Content of Maternal

Milk: Influence of the Stage of Lactation, Lipid Composition, and Vitamin K1 Supplements Given to the Mother. _Pediatr Res_ 22, 513–517 (1987).

https://doi.org/10.1203/00006450-198711000-00007 Download citation * Received: 01 October 1986 * Accepted: 10 June 1987 * Issue Date: 01 November 1987 * DOI:

https://doi.org/10.1203/00006450-198711000-00007 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative