The effect of naloxone on the hemodynamics of the newborn piglet with septic shock

ABSTRACT ABSTRACT. Naloxone has been shown to reverse the hemodynamic sequelae of experimental septic shock in adult animal models. Its effectiveness in the newborn has not been studied. To

further investigate the efficacy of naloxone, we instrumented 18 piglets for continuous measurement of mean arterial pressure, mean pulmonary arterial pressure, central venous pressure,

heart rate, left ventricular pressure, contractility, cardiac output, and O2. Oxygen consumption, systemic vascular resistance, and pulmonary vascular resistance were calculated. Following a

stabilization period, group B β-hemolytic Streptococci were infused over 30 min. Following the infusion, naloxone (1 mg/kg) was given followed by a continuous infusion of 1 mg/kg/h in nine

treatment animals. Nine control animals were given an equal volume of saline. Both groups developed significant increases in mean pulmonary arterial pressure followed by a return to

baseline. Oxygen consumption, cardiac output, contractility and mean arterial pressure decreased in both groups. Treatment with naloxone was associated with a cessation in the fall in the

mean arterial pressure and the contractility. The difference in mean arterial pressure and contractility between groups was significant. The naloxone group had significantly improved 5–h

survival. We speculate that naloxone may reverse some of the hemodynamic sequelae and improve survival in newborns with septic shock. SIMILAR CONTENT BEING VIEWED BY OTHERS DOSE-RELATED

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SHOCK Article Open access 16 February 2022 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics and Pathology, The Ohio State University and Children's

Hospital, Columbus, 43205, Ohio Randy R Miller, James A Menke, Nancy B Hansen, David L Zwick, Rex G Bickers & Philip T Nowicki Authors * Randy R Miller View author publications You can

also search for this author inPubMed Google Scholar * James A Menke View author publications You can also search for this author inPubMed Google Scholar * Nancy B Hansen View author

publications You can also search for this author inPubMed Google Scholar * David L Zwick View author publications You can also search for this author inPubMed Google Scholar * Rex G Bickers

View author publications You can also search for this author inPubMed Google Scholar * Philip T Nowicki View author publications You can also search for this author inPubMed Google Scholar

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Miller, R., Menke, J., Hansen, N. _et al._ The Effect of Naloxone on the Hemodynamics of the Newborn

Piglet with Septic Shock. _Pediatr Res_ 20, 707–710 (1986). https://doi.org/10.1203/00006450-198608000-00001 Download citation * Received: 07 October 1985 * Accepted: 12 March 1986 * Issue

Date: 01 August 1986 * DOI: https://doi.org/10.1203/00006450-198608000-00001 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

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