187 hypothermia decreases intrapulmonary shunt in dogs

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187 hypothermia decreases intrapulmonary shunt in dogs"


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ABSTRACT The effect of hypothermia on respiratory failure has not been studied. One possible advantage of hypothermia in respiratory failure is the reduction of cardiac output, which may in


turn lower intrapulmonary shunting. We measured venous admixture and other cardiorespiratory variables in 5 anesthetized adult dogs before and after surface cooling to 30°C, and again after


isovolemic hemodilution with Dextran 75. Arterial blood gases and hemoglobin saturations were corrected for temperature. Cardiac output was calculated from oxygen consumption, which was


measured directly using a closed circuit method. Caridorespiratory variables measured at baseline (38°C), during hypothermia (30°C) and during hypothermia and hemodilution (30°C+H) are shown


in the table below. (x ± SEM, *p<.05) Venous admixture fell dramatically in 4 out of 5 dogs (from .24 ± .05 to /08 ± .02, x SEM, p<.Ol). Hypothermia decreases intrapulmonary shunt in


dogs and may be useful in patients with respiratory failure. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Anesthesia, Harvard Medical School, The Children's


Hospital, Boston Mare B Hershenson, James A Schena, Robert K Crone & Allan W Walker Authors * Mare B Hershenson View author publications You can also search for this author inPubMed 


Google Scholar * James A Schena View author publications You can also search for this author inPubMed Google Scholar * Robert K Crone View author publications You can also search for this


author inPubMed Google Scholar * Allan W Walker View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT


THIS ARTICLE CITE THIS ARTICLE Hershenson, M., Schena, J., Crone, R. _et al._ 187 HYPOTHERMIA DECREASES INTRAPULMONARY SHUNT IN DOGS. _Pediatr Res_ 19, 142 (1985).


https://doi.org/10.1203/00006450-198504000-00217 Download citation * Issue Date: 01 April 1985 * DOI: https://doi.org/10.1203/00006450-198504000-00217 SHARE THIS ARTICLE Anyone you share the


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