187 hypothermia decreases intrapulmonary shunt in dogs

ABSTRACT The effect of hypothermia on respiratory failure has not been studied. One possible advantage of hypothermia in respiratory failure is the reduction of cardiac output, which may in

turn lower intrapulmonary shunting. We measured venous admixture and other cardiorespiratory variables in 5 anesthetized adult dogs before and after surface cooling to 30°C, and again after

isovolemic hemodilution with Dextran 75. Arterial blood gases and hemoglobin saturations were corrected for temperature. Cardiac output was calculated from oxygen consumption, which was

measured directly using a closed circuit method. Caridorespiratory variables measured at baseline (38°C), during hypothermia (30°C) and during hypothermia and hemodilution (30°C+H) are shown

in the table below. (x ± SEM, *p<.05) Venous admixture fell dramatically in 4 out of 5 dogs (from .24 ± .05 to /08 ± .02, x SEM, p<.Ol). Hypothermia decreases intrapulmonary shunt in

dogs and may be useful in patients with respiratory failure. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Anesthesia, Harvard Medical School, The Children's

Hospital, Boston Mare B Hershenson, James A Schena, Robert K Crone & Allan W Walker Authors * Mare B Hershenson View author publications You can also search for this author inPubMed 

Google Scholar * James A Schena View author publications You can also search for this author inPubMed Google Scholar * Robert K Crone View author publications You can also search for this

author inPubMed Google Scholar * Allan W Walker View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Hershenson, M., Schena, J., Crone, R. _et al._ 187 HYPOTHERMIA DECREASES INTRAPULMONARY SHUNT IN DOGS. _Pediatr Res_ 19, 142 (1985).

https://doi.org/10.1203/00006450-198504000-00217 Download citation * Issue Date: 01 April 1985 * DOI: https://doi.org/10.1203/00006450-198504000-00217 SHARE THIS ARTICLE Anyone you share the

following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer

Nature SharedIt content-sharing initiative