Normalizing functional residual capacity (frc) in rds

ABSTRACT PEEP is used in infants with RDS to counter atelectasis and maintain FRC. FRC is controlled by PEEP yet blood gases, not FRC, are the bases for selecting ventilator settings. To

test the hypothesis that maintenance of normal FRC leads to improved pulmonary function and reduced mortality, six paired twin lambs delivered prematurely (125-132 days, term is 147) were

ventilated, initially, with peak inspiratory pressures (PIP) of 32 cm H2O, 6 cm H2O PEEP, 0.33 sec inspiratory time and 60 BPM while on 100% O2 and then monitored for 24 hr. In the control

group ventilator settings were adjusted using criteria based on arterial blood gas analyses. In the study group, FRC was maintained within normal limits (25±2SE ml/kg) by adjusting PEEP. The

study group FRC on the initial PEEP of 6 cm H2O ranged from 9 to 55 ml/ kg. PEEP required adjustment in 5 of these 6 lambs. Mean PIP, PEEP and mean airway pressures (Paw) during the 1st 8

hr of life were 29.6, 5.5 and 7.1 cm H2O (study group) and 40.4, 2.8 and 6.8 cm H2O (control). Of the 12 lambs studied, 6 died before 24 hr; 4 control and 2 from the study group. Even though

Paw of the two groups were not different for the 8 hr period, PaO2/FiO2 of the study group was significantly greater than the control group (156±20 vs 112±16 mmHg). Also, the driving

pressure (PIP-PEEP) was less in the study group, yet, PaCO2 was significantly less in the study group than the control group (28±2 vs 39±3 mmHg). These preliminary data suggest that the

normalization of FRC improves pulmonary function and may reduce mortality of lambs with RDS. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept. of Peds., Univ. of Utah Med.

Center, Salt Lake City, UT P Richardson, C Bose, F Gonzalez, G King, N Shaw & J Carlstrom Authors * P Richardson View author publications You can also search for this author inPubMed 

Google Scholar * C Bose View author publications You can also search for this author inPubMed Google Scholar * F Gonzalez View author publications You can also search for this author

inPubMed Google Scholar * G King View author publications You can also search for this author inPubMed Google Scholar * N Shaw View author publications You can also search for this author

inPubMed Google Scholar * J Carlstrom View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE

CITE THIS ARTICLE Richardson, P., Bose, C., Gonzalez, F. _et al._ NORMALIZING FUNCTIONAL RESIDUAL CAPACITY (FRC) IN RDS. _Pediatr Res_ 18 (Suppl 4), 343 (1984).

https://doi.org/10.1203/00006450-198404001-01499 Download citation * Issue Date: 01 April 1984 * DOI: https://doi.org/10.1203/00006450-198404001-01499 SHARE THIS ARTICLE Anyone you share the

following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer

Nature SharedIt content-sharing initiative