557 decreased bone mineral content (bmc) in breast-fed infants without supplemental vitamin d (d): “catch up” mineralization at 6 months and one year; possible. Effects on length

ABSTRACT We previously reported a double blind randomized prospective study of 9 exclusively breast-fed infants without supplemental D (placebo, plac) and 9 exclusively breast-fed infants on

supplement of 400 IU D/d (suppl.); 12 infants were fed exclusively Similac 20 cal/oz (form). As reported, at 3 mos plac had significantly lower BMC (modified photon absorptiometry) and

serum 25-OH D. By 6 mos, serum 25-OHD had decreased and was still lower in plac vs suppl. (12.9±4.0 SE vs 32.7±4.1ng/ml. p<.01). BMC at 6 mos was 70±6, 75±5, and 94±7mg/cm for plac suppl.

and form; plac and suppl. did not differ; plac was less than form (p<.05). After 6 mos, the study was unblinded, infants received solids and breast-fed infants received 400 IU D/d. 10

form and 13 breast-fed infants were seen at 12 mos, when serum 25-OHD, parathyroid hormone, calcitonin, Ca, P, Mg and alkaline phosphatase did not differ between plac and suppl. BMC at 12

mos was 120±19, 108±20, and 132±8mg/cm for plac, suppl. and form and did not differ; grps did not differ in wt, but plac was shorter (73.3±.38cm) than suppl. (75.8± .89cm, p<.1) or form

(75.8±0.32cm, p<.02); one way analysis of variance for 3 grps, p<.05. Thus, vitamin D supplements may be necessary for optimal bone mineralization in breast-fed infants but “catchup”

mineralization may occur in infants not given D initially. We speculate that D supplements may also be necessary for optimal body length in breast-fed infants. ARTICLE PDF AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * U Cincinnati, F R Greer, J E Searcy, R S Levin, J J Steichen & R C Tsang Authors * F R Greer View author publications You can also search for this author

inPubMed Google Scholar * J E Searcy View author publications You can also search for this author inPubMed Google Scholar * R S Levin View author publications You can also search for this

author inPubMed Google Scholar * J J Steichen View author publications You can also search for this author inPubMed Google Scholar * R C Tsang View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Greer, F., Searcy, J., Levin, R. _et al._ 557 DECREASED BONE

MINERAL CONTENT (BMC) IN BREAST-FED INFANTS WITHOUT SUPPLEMENTAL VITAMIN D (D): “CATCH UP” MINERALIZATION AT 6 MONTHS AND ONE YEAR; POSSIBLE.EFFECTS ON LENGTH. _Pediatr Res_ 15 (Suppl 4),

533 (1981). https://doi.org/10.1203/00006450-198104001-00570 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00570 SHARE THIS ARTICLE Anyone

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