446 endocrine functions during cardiac surgery in hypotherhia

ABSTRACT Hyperglycemia and hypocalcemia frequently complicate open heart surgery (OHS) in hypothermia (HOTH). We have studied 21 children (8wks-6yrs) before, during, and after OHS in HOTH

and determined serum glucose (G), insulin (IN), growth hormone (GH), calcium (Ca) calcitonin (CT), and thyroid concentrations: IN conc. were suppressed during HOTH with an attendant increase

in serum G levels. During rewarming, IN rebounded rapidly but transiently, suggesting insufficient hormone reserve. Ca declined during HOTH, but increased with rewarming. CT showed no

variation with changing body temp. or Ca conc. GH increased with HOTH and post-arrest rewarming, but returned to normal within one hr of surgery. Preliminary thyroid studies suggested

decreasing TSH and T4 with HOTH, which returned to baseline upon rewarming. CONCLUSION: OHS in HOTH is associated with profound endocrine changes. Their understanding may greatly aid in the

management of OHS patients and improve surgical outcome. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * UAMS, Depts. of Pediatr., Anesthesiol., and Surg., Little Rock, AR.

Heinrich Schedewie, Astrid Seifen, Joycelyn Elders, Louis Pryor, Thomas Hart & Doyne Williams Authors * Heinrich Schedewie View author publications You can also search for this author

inPubMed Google Scholar * Astrid Seifen View author publications You can also search for this author inPubMed Google Scholar * Joycelyn Elders View author publications You can also search

for this author inPubMed Google Scholar * Louis Pryor View author publications You can also search for this author inPubMed Google Scholar * Thomas Hart View author publications You can also

search for this author inPubMed Google Scholar * Doyne Williams View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Schedewie, H., Seifen, A., Elders, J. _et al._ 446 ENDOCRINE FUNCTIONS DURING CARDIAC SURGERY IN HYPOTHERHIA. _Pediatr Res_ 15 (Suppl 4), 514

(1981). https://doi.org/10.1203/00006450-198104001-00457 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00457 SHARE THIS ARTICLE Anyone you

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