349 effect of intravenous (iv) infusion methods on availa-bility of chloramphenicol (c) and its succinate ester (cs)

ABSTRACT The rate of IV drug delivery is affected by many factors including characteristics of the drug, IV flow rate, and site of injection into the system. Because of the frequent use of

CS in pediatric patients, we examined the rate of CS delivery from a standard pediatric IV infusion set (BuretrolR-Travenol). Using 3 flow rates, and 3 injection sites (buretrol, y site,

flashball), timed samples of the IV fluid delivered from the set were collected for 6 hr and analyzed for CS by an HPLC method. We found large differences in the delivery time (min) for 95%

of the injected CS: To assess the clinical significance of these differences, CS and C steady state serum concentrations (6 samples over 6 hr; measured by HPLC) were studied in fifteen

patients (age 0.2-15 yr) receiving CS, 25 mg/kg, injected into the buretrol and flashball on consecutive days. Flashball injections resulted in higher peak CS cone (p<0.001) and peak C

cone (p<0.005) in a shorter time from the start of infusion (p<0.005). At flow rates >7 m1/hr, trough cone and area under the curve were similar with the two sites. These data show

the importance of defining IV flow rates and drug injection sites when monitoring single serum CS or C cone or when calculating kinetic parameters. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * The Ohio State Univ Colleges of Med and Pharm, & Children's Hosp Dept of Peds, Columbus, Ohio Milap C Nahata, Dwight A Powell, John P Glazer & Milo D Hilty

Authors * Milap C Nahata View author publications You can also search for this author inPubMed Google Scholar * Dwight A Powell View author publications You can also search for this author

inPubMed Google Scholar * John P Glazer View author publications You can also search for this author inPubMed Google Scholar * Milo D Hilty View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nahata, M., Powell, D., Glazer, J. _et al._ 349 EFFECT OF INTRAVENOUS

(IV) INFUSION METHODS ON AVAILA-BILITY OF CHLORAMPHENICOL (C) AND ITS SUCCINATE ESTER (CS). _Pediatr Res_ 15 (Suppl 4), 498 (1981). https://doi.org/10.1203/00006450-198104001-00360 Download

citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00360 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative