316 captopril in the treatment of uncontrollable high-renin hypertension in children

ABSTRACT Captopril(C), an orally active inhibitor of angiotensin I converting enzyme, might be effective in the management of high-renin HTN. However, almost nothing is known about the

effects of C in children. We have used C in 5 children (1.8 to 14.8 yrs) with uncontrollable high-renin HTN (PRA=21±6.3 ng/ml/hr, mean ± SEM). All patients (PT) had HTN secondary to severe

parencymal or arterial renal disease. Vasodilator drugs were stopped in all 5 PT before starting C. C was started at 0.3 mg/kg/dose every 8-12 hours, and the final dosages ranged from 0.8 to

5.3 mg/kg/day. The 5 children have been on C from 4 to 15 months (mean=9 months). The blood pressure (BP;mmHg) response to C is shown in the following table. After starting C, other

antihypertensive drugs were completely stopped in 1 PT and decreased in 3 PT. The only adverse reactions attributed to C were nausea and vomiting. It is concluded that C is effective for

long-term control of BP in children with high-renin HTN uncontrolled by currently available drugs. Thus far, there have been a minimum of adverse reactions to C, and dosages of other

antihypertensive drugs can often be decreased after control of HTN by C. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Jessica T. Weinberger. Dept. of Peds., Vanderbilt Univ.,

Nashville, 37232, Tennessee Robert C Boerth & Robert C Macdonell Jr. Authors * Robert C Boerth View author publications You can also search for this author inPubMed Google Scholar *

Robert C Macdonell Jr. View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Boerth, R., Macdonell, R. 316 CAPTOPRIL IN THE TREATMENT OF UNCONTROLLABLE HIGH-RENIN HYPERTENSION IN CHILDREN. _Pediatr Res_ 15 (Suppl 4), 492 (1981).

https://doi.org/10.1203/00006450-198104001-00327 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00327 SHARE THIS ARTICLE Anyone you share the

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