184 effects of propranolol administration on shr rats and their newborns

ABSTRACT Propranolol (P), 20 mg/kg, was administered via daily orogastric intubation to 12 spontaneously hypertensive Okomoto Aoki female rats starting at 6 weeks of age. We studied the

effects of P on maternal blood pressure (BP) and neonatal weight gain, litter size and cardiac function. Controls were 8 intubated and 8 non-intubated SHR females. Tail BP's were

measured weekly. All 3 groups were hypertensive by 10-12 weeks of life. Rats were mated with SHR males at 12-18 weeks of age. BP (170-190 mm) did not differ among the 3 groups during

pregnancy (P>.05) but at term BP fell markedly (P<.05). There were no significant differences in maternal weight gain, litter size and pup weights. Pup hearts from each group were

studied the day before delivery, day of birth (day 0), and day 1 by excising the right atria, superfusing them with Tyrode's solution and recording surface electrograms during

spontaneous beating before and after superfusion with epinephrine (epi) 10−7−10−5M. There were no differences in fetal and day 0 spontaneous atrial rates and response to epi, but on day 1 a

significantly greater response to epi occurred in P pups. Thus, although no β-blockade was demonstrated in the fetuses and neonates, rebound supersensitivity to epi occurred. In summary,

whereas P did not alter maternal BP, litter size or weight, a potentially toxic effect of P was noted in the neonate. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Columbia

University, College of Physicians & Surgeons, Dept. of Pediatrics, New York Tove S Rosen, John Mill, Michael Rosen & Welton Gersony Authors * Tove S Rosen View author publications

You can also search for this author inPubMed Google Scholar * John Mill View author publications You can also search for this author inPubMed Google Scholar * Michael Rosen View author

publications You can also search for this author inPubMed Google Scholar * Welton Gersony View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rosen, T., Mill, J., Rosen, M. _et al._ 184 EFFECTS OF PROPRANOLOL ADMINISTRATION ON SHR RATS AND THEIR NEWBORNS.

_Pediatr Res_ 15 (Suppl 4), 470 (1981). https://doi.org/10.1203/00006450-198104001-00193 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00193

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