1529 minimal change nephrotic syndrome (mcns): an autoimmune disease?

ABSTRACT The presence of low-level tissue directed antibodies (AAb's) and immune complexes (IC) were determined in 12 MCNS and 5 mesangial proliferative glomerulonephritis (MesPGN)

patients with biopsy proven disease. The AAb's were detected by immunofluor-escence (IF) against human cadaveric tissues and the IC detected by 3 different methods and isolated by

polyethylene glycol precipitation/sedimentation. The isolated antibodies from the IC were also tested by IF for AAb activity against the same tissue antigen battery. The presence of such AAb

activity was demonstrated in 8/12 MCNS and in all of the MesPGN sera. In the MCNS group 7/8 of the AAb positive sera also contained IC with corresponding AAb activity (2/7 directed against

smooth muscle antigens and 5/7 directed against kidney tubular microsomes). The MesPGN group all reacted against kidney basement membrane antigens but no other tissue antigen. Of these 3/5

also demonstrated the presence of IC which contained AAb reactive with the same kidney antigen. The presence of such AAb's and their formation of IC indicates that these antibodies may

have a functional role in the initial immunological insult to the kidney. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Depts of Peds & Path. Georgetown Univ. Med. Ctr.,

Wash., D.C. Terry Phillips, Leticia U Tina, Pedro A Jose, Zoe L Papadopoulou & Philip L Calcagno Authors * Terry Phillips View author publications You can also search for this author

inPubMed Google Scholar * Leticia U Tina View author publications You can also search for this author inPubMed Google Scholar * Pedro A Jose View author publications You can also search for

this author inPubMed Google Scholar * Zoe L Papadopoulou View author publications You can also search for this author inPubMed Google Scholar * Philip L Calcagno View author publications You

can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Phillips, T., Tina, L., Jose, P. _et al._ 1529

MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS): AN AUTOIMMUNE DISEASE?. _Pediatr Res_ 15 (Suppl 4), 698 (1981). https://doi.org/10.1203/00006450-198104001-01552 Download citation * Issue Date: 01

April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01552 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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