1374 phenylephrine infusion as a model for the hemodynamic sequelae of group b beta strep (gbs) bacteremia in the newborn piglet

ABSTRACT Newborn piglets exposed to GBS bacteremia consistently demonstrate vascular hyper-resistance, diminished blood flow, elevated pulmonary artery pressure, and preserved systemic blood

pressure. We evaluated the possibility of endogenous alpha sympathetic mediation of these hemodynamic events by observing effects of exogenous phenylephrine (alpha agonist) infusion in the

newborn piglet. Newborn piglets (1-5 wks) were intubated, paralyzed, and monitored for aortic pressure(AOP), pulmonary artery pressure(PAP), left atrial pressure(LAP), pulmonary artery blood

flow, taken as cardiac output(QPA), and mesenteric artery blood flow(QMES). Peripheral resistance(RTP), pulmonary artery resistance(RPA), & mesenteric resistance(RMES) were calculated.

LAP was held constant. After control observations, phenylephrine was infused @ 2-8mcg/kg/min. Within 40 mins. QPA & QMES fell to 70% & 69% of control, while AOP & PAP rose to

145% & 118% of control. RTP, RMES, & RPA rose to 215%, 210% & 173% of control. These results were then compared to our previously reported sequelae of GBS infusion. Conclusions:

1. GBS and phenylephrine both produce comparably diminished QPA & QMES. 2. For the same decrease in QPA, phenylephrine raises AOP more(145%vs108%) and PAP much less(118%vs360%) than does

GBS. 3. Phenylephrine consistently increases RTP more than RPA(215% vs 173%) whereas GBS raises RPA much more than RTP (490%vs150%). 4. Hemodynamic sequelae of GBS are likely mediated by

more than simply alpha effect. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept. of Pediatrics, U. of Chicago & iDept. of Surgery and Cardiac Surgery, Michael Reese

Hospital, Chicago W Meadow, P Meus & M O Beem Authors * W Meadow View author publications You can also search for this author inPubMed Google Scholar * P Meus View author publications

You can also search for this author inPubMed Google Scholar * M O Beem View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Meadow, W., Meus, P. & Beem, M. 1374 PHENYLEPHRINE INFUSION AS A MODEL FOR THE HEMODYNAMIC SEQUELAE OF GROUP B BETA STREP (GBS)

BACTEREMIA IN THE NEWBORN PIGLET. _Pediatr Res_ 15 (Suppl 4), 672 (1981). https://doi.org/10.1203/00006450-198104001-01403 Download citation * Issue Date: 01 April 1981 * DOI:

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