1352 incomplete suppression of neonatal glucose production by exogenous glucose

ABSTRACT Incomplete suppression of glucose production (GP) during exogenous glucose infusions has been reported in newborns within the first 3 hours of life (Ped. Res. 14:576, 1980) and in

prematures (Ped. Res. 14:586, 1980). To further evaluate the effects of birth weight, gestational age, and postnatal age on this process, we infused eight infants with [6,6−2H2]glucose prior

to and after beginning an infusion of exogenous glucose at a rate approximately equal to normal neonatal hepatic glucose output (5 mg kg-1-min-1). The study subjects ranged from gestational

ages of 32-40 weeks, had birth weights between 1320 and 4140 grams, and were studied between 14 hours and 5 days after birth. None was hypoglycemic prior to or during the study. Basal GP

averaged 5.02 ± 0.43 mg·kg-1 min-1. Exogenous glucose infusion produced incomplete suppression of GP in all infants averaging 50 ± 9% (range 3-72%). The degree of suppression did not

correlate with gestational age, birthweight, or with postnatal age. However, there tended to be an inverse relationship between the degree of suppression of GP and the difference between the

plasma glucose concentration before and after the exogenous glucose infusion. Thus, failure of complete suppression of GP in the newborn is present throughout the immediate postnatal

period. Also, those infants with less suppression of GP tend to become more hyperglycemic during such infusions. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of

Pediatrics, Harbor-UCLA Medical Center and Washington University, Los Angeles and St. Louis Rosemary D Leake, Carolyn Waters, Irene E Karl & Dennis M Bier Authors * Rosemary D Leake View

author publications You can also search for this author inPubMed Google Scholar * Carolyn Waters View author publications You can also search for this author inPubMed Google Scholar * Irene

E Karl View author publications You can also search for this author inPubMed Google Scholar * Dennis M Bier View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Leake, R., Waters, C., Karl, I. _et al._ 1352 INCOMPLETE SUPPRESSION OF NEONATAL GLUCOSE

PRODUCTION BY EXOGENOUS GLUCOSE. _Pediatr Res_ 15 (Suppl 4), 668 (1981). https://doi.org/10.1203/00006450-198104001-01381 Download citation * Issue Date: 01 April 1981 * DOI:

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