1350 effects of rate of volume expansion on brain blood flow after asphyxia and hypotension in the piglet

ABSTRACT The rate at which the systemic arterial blood pressure (SABP) is restored after asphyxial and hypotensive insults may be a factor in the pathogenesis of perinatal central nervous

system lesions. To examine this, brain blood flow (BBF) was determined in 16 newborn piglets during asphyxia, superimposed hypotension and subsequent volume expansion (15 ml/kg, plasmanate).

Asphyxia (A) was produced by a respiratory dead space and hypotension (H) by phelbotomy. Group 1 received plasmanate in 3 min., Group 2 in 30 min. and Group 3 received none. BBF

(microsphere technique) was measured with each insult and at 5 and 30 min. after the start of the volume expansion and removal of the dead space. Results were (M±SEM): *p<.02 as compared

to control, +p<.05 as compared to Group 3. SABP was reduced (p<.05) in Group 3 at 5 min. after A and H. All groups had significant reductions in hematocrit from control at the

completion of the study. At autopsy, intracranial hemorrhage was not observed. The data indicate that 1) the rate of volume expansion did not influence the magnitude of BBF and 2) the higher

BBF at the completion of volume expansion probably reflects compensation for anemia to achieve adequate oxygen delivery. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Brown

Univ. Prog, in Med., Women & Infants Hosp., Dept. of Ped., Providence, RI A Laptook, B S Stonestreet & W Oh Authors * A Laptook View author publications You can also search for this

author inPubMed Google Scholar * B S Stonestreet View author publications You can also search for this author inPubMed Google Scholar * W Oh View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Laptook, A., Stonestreet, B. & Oh, W. 1350 EFFECTS OF RATE OF

VOLUME EXPANSION ON BRAIN BLOOD FLOW AFTER ASPHYXIA AND HYPOTENSION IN THE PIGLET. _Pediatr Res_ 15 (Suppl 4), 668 (1981). https://doi.org/10.1203/00006450-198104001-01379 Download citation

* Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01379 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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