1091 age related response to hemophilus influenzae type b vaccines

ABSTRACT Safety and age related immunogenicity of 2 HIB vaccines, prepared by Lederle Laboratories, polyribosylribitol phosphate (PRP) and PRP-pertussis (PRP-p) were compared in 3 groups of

normal children aged 6-7 months,15-18 months and 3-6 years. Children in the older age groups received a single dose of 1 of the HIB vaccines or DPT. Children aged 6-7 months received either:

1) 2 monthly doses of an HIB vaccine, 2) DPT followed 1 month later by PRP or 3) PRP-p followed by DPT. Reactions were evaluated at 24 hours and RIA antibody (method of Anderson) determined

at 1 month after injections. In the 2 older age groups,mild-moderate local and/or systemic reactions were similar for PRP-p (4/10 injections) and DPT (5/10 injections). PRP was without

reactions. 6-7 month old children tolerated PRP-p and PRP equally well with 3/31 and 4/31 injections causing reactions. In contrast, 12/22 DPT injections caused reactions. Serologic

responses to both HIB vaccines were age dependent. The ratio of post-pre geometric mean titers: The addition of pertussis to PRP enhanced antibody response to the HIB polysaccharide antigen

and holds promise as an approach to immunization. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Vanderbilt Univ.Med.Sch.Dept. of Peds., Nashville Peter F Wright, Deborah M Burks,

 Diane J Pincus, Claudia S Andrews, Eileen M Lawrence & Sarah H Sell Authors * Peter F Wright View author publications You can also search for this author inPubMed Google Scholar *

Deborah M Burks View author publications You can also search for this author inPubMed Google Scholar * Diane J Pincus View author publications You can also search for this author inPubMed 

Google Scholar * Claudia S Andrews View author publications You can also search for this author inPubMed Google Scholar * Eileen M Lawrence View author publications You can also search for

this author inPubMed Google Scholar * Sarah H Sell View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Wright, P., Burks, D., Pincus, D. _et al._ 1091 AGE RELATED RESPONSE TO HEMOPHILUS INFLUENZAE TYPE B VACCINES. _Pediatr Res_ 15 (Suppl 4), 624 (1981).

https://doi.org/10.1203/00006450-198104001-01117 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01117 SHARE THIS ARTICLE Anyone you share the

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