1027 cytomegalovirus (cmv) serology in sudden infant death syndrome (sids): lack of correlation with chlamydia trachomatis serology

ABSTRACT We found Chlamydia trachomatis (C.t.) seropositivity to be significantly more frequent in SIDS than living controls. Because infection with CMV has been proposed to act

synergistically with C.t. in producing infant respiratory infection and in utero viral infections have been postulated to play a role in SIDS, CMV complement fixing antibody titers were

measured in serum from 29 SIDS, age 12.3±5.8wks, and 23 living hospitalized controls (C), age 13.5±6.7wks on which C.t. immunofluorescent antibody serologies had been performed. Cord blood

(CB) from 19 black lower socioeconomic infants was similarly studied. Although 34% of SIDS were CMV seropositive, suggesting previous or ongoing maternal CMV infection, this was not

different from controls. Only 4 of 11 SIDS with high C.t. titers (≥1:1024) were CMV seropositive, all at low titers. Although CMV and C.t. titers were correlated (r= .48, p<.05) in cord

blood, C.t. and CMV titers were not correlated in SIDS or controls. Thus, there is no evidence for a higher incidence of maternal experience with CMV in SIDS or for a postnatal association

of CMV seropositivity with C.t. seropositivity. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Wash. Univ. Med. Sch., St. Louis Children's Hosp., Dept. Ped., and Jewish Hosp.

of St. Louis, Dept. Med., St. Louis, MO. Laura S Hillman & Morey Gardner Authors * Laura S Hillman View author publications You can also search for this author inPubMed Google Scholar *

Morey Gardner View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Hillman, L., Gardner, M. 1027 CYTOMEGALOVIRUS (CMV) SEROLOGY IN SUDDEN INFANT DEATH SYNDROME (SIDS): LACK OF CORRELATION WITH CHLAMYDIA TRACHOMATIS SEROLOGY. _Pediatr Res_ 15 (Suppl 4), 614

(1981). https://doi.org/10.1203/00006450-198104001-01053 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01053 SHARE THIS ARTICLE Anyone you

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