985 clinical efficacy and pharmacokinetics (pk) of moxalactam (mlm) in pediatric skeletal infections

ABSTRACT The clinical efficacy and PK of the new β-lactam antibiotic, MLM, was investigated in 8 pediatric patients (8 wks.-16 yrs.) with skeletal infections. All patients received 150

mg/k/day IV in 3 divided doses for 1-4 weeks. Five children had osteomyelitis 3 with S. aureus, 1 with Serratia spp., and 1 with K. pneumoniae. Two had purulent synovial fluid without

recovery of an organism. One had both osteomyelitis and septic arthritis due to S. aureus. All children demonstrated clinical improvement within 48 hrs. of the initiation of therapy. No

drug-related toxicity was noted. In all cases, cultures at the termination of therapy were sterile. Ultimately, all had normal musculoskeletal function. After the initial dose and again

after 3-5 days of therapy the PK of MLM were determined. A new, HPLC technique was used to measure serum concentrations. No difference in PK parameters was observed at the two time

intervals. Mean peak serum concentrations were 235±48 μg/ml and exceeded the MIC's of the separate organisms for at least 3 hrs. No drug accumulation occurred during continuous therapy.

The t½β was 100±31 min. and was independent of patient age. The apparent volume of distribution was ∼0.45 L/kg suggesting good tissue penetration. We conclude that MLM is a safe, effective

antimicrobial agent for the treatment of skeletal infections in childhood. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics and Orthopaedics, Case Western

Reserve University, Rainbow Babies and Children's Hospital, Cleveland Stephen C Aronoff, Peter V Scoles, Michael D Reed, Carolyn Meyers, Joseph S Bertino, Jeffrey L Blumer & W T

Speck Authors * Stephen C Aronoff View author publications You can also search for this author inPubMed Google Scholar * Peter V Scoles View author publications You can also search for this

author inPubMed Google Scholar * Michael D Reed View author publications You can also search for this author inPubMed Google Scholar * Carolyn Meyers View author publications You can also

search for this author inPubMed Google Scholar * Joseph S Bertino View author publications You can also search for this author inPubMed Google Scholar * Jeffrey L Blumer View author

publications You can also search for this author inPubMed Google Scholar * W T Speck View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Aronoff, S., Scoles, P., Reed, M. _et al._ 985 CLINICAL EFFICACY AND PHARMACOKINETICS (PK) OF MOXALACTAM (MLM) IN

PEDIATRIC SKELETAL INFECTIONS. _Pediatr Res_ 15 (Suppl 4), 606 (1981). https://doi.org/10.1203/00006450-198104001-01010 Download citation * Issue Date: 01 April 1981 * DOI:

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