979 immunological abnormalities in juvenile rheumatoid arthritis (jra)

ABSTRACT The sera of twe nty five patients with JRA and the skin of ten of them were studied. Six patients had typical JRA rash. Their ages ranged from 5 to 15 years. Twelve patients with

JRA demonstrated elevated levels of immune complexes (IC). The IC decreased during treatment and control of the disease. Five patients showed the presences of rheumatoid factor and

antinuclear antibodies. There was good correlation between these abnormalities and treatment. The sera complement levels were normal in twenty patients. Punch biopsies were obtained from the

site of rash or normal skin (control). Immunofluorescence staining revealed deposition of immunoglobulins or complement in 8 patients, six of whom had the rash and had systemic onset of

disease. The fluorescence was positive for IgM (8), C3 (4) and IgG (1)mainly at the dermal-epidermal junction and vessels. Controls were negative. These data suggest, 1) positivity of IC in

some aptients with JRA.2) Good correlation between IC and disease activity and, 3)The rash probably is immunological mediated. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Clinica Nova, Monterrey N.L. and Unidad de investigaciones Biomedicas, Guadalajara Jal, Mexico Carlos M Arroyave & Silvia Mejia Authors * Carlos M Arroyave View author publications You

can also search for this author inPubMed Google Scholar * Silvia Mejia View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Arroyave, C., Mejia, S. 979 IMMUNOLOGICAL ABNORMALITIES IN JUVENILE RHEUMATOID ARTHRITIS (JRA). _Pediatr Res_ 15 (Suppl 4), 605 (1981).

https://doi.org/10.1203/00006450-198104001-01004 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01004 SHARE THIS ARTICLE Anyone you share the

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